DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_SPOP_SBC_1

Location: 705:709

E3 ligase: SPOP

DEGRON score: 0.8542

ASA_SCORE: 89.08

COIL: 0.9682

CONS_SCORE: 0.4014

DSS_SCORE: 0.6952

HELIX: 0.0126

FCONS_SCORE: 0.865

RIG_SCORE: 0.5423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A719T	TCGA-AA-A010	COAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0556
p.T712M	TCGA-AP-A1DM	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.25
p.T712M	DO43106	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.T712M	SIDM01139	Pancreatic Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.25
p.T712M	PANC-02-03	pancreas	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.25
p.A700V	DO234272	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.V697F	DO228900	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1111
p.T714A	SIDM01149	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.T714A	ACH-001365	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.1944
p.T714A	NCI-H847	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.A713T	SIDM00217	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.A713T	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.2222
p.A713T	SNU-1040	large_intestine	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.S709N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7069
p.S709N	ACH-001127	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	0.7069
p.S709N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with MBD6 mutations

All proteins holding degron of PPTSS