DegronMD - Q9H1J1(UPF3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R64K	DO230849	AML	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7237
p.V70L	DO222497	BTCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO222867	BTCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO222857	BTCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO230522	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO230986	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO52354	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO231096	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO230463	PACA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO51465	PACA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO35406	PACA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO229167	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO229103	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO229211	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.V70L	DO231338	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5654
p.R74L	DO229034	LICA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.G55S	DO50894	LICA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.G55S	DO50894	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667
p.G55S	DO229103	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.G55S	DO229103	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667
p.A17S	DO50921	LICA	ICGC	GREKLSALE	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.E41V	DO27279	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2222
p.R64G	DO229133	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7568
p.V71I	DO229180	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5965
p.L26M	DO229216	THCA	ICGC	GREKLSALE	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.711
p.S68G	DO229229	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6993
p.P59S	DO229221	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.P59S	DO229221	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.0556
p.G57D	DO229242	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.G57D	DO229242	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1111
p.A66S	SIDM01242	Melanoma	GDSC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6477
p.A66S	SIDM00243	Other Solid Cancers	GDSC	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6477
p.S48L	SIDM01003	T-Lymphoblastic Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7667
p.S48L	ACH-000101	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7667
p.S48L	ACH-000700	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7667
p.S48L	ACH-001411	Bladder Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7667
p.E61D	ACH-000371	Lymphoma	CCLE	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.G55R	ACH-001344	Neuroblastoma	CCLE	KRTALSKVV	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.G55R	ACH-001344	Neuroblastoma	CCLE	PPTSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667

Kaplan plot for UPF3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UPF3A

UniProt ID: Q9H1J1

Entrez ID: 65110

Protein name: Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UPF3A in