DegronMD

Uniprot ID: Q9H1J1

Source protein: Regulator of nonsense transcripts 3A

Source gene: UPF3A

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7136

ASA_SCORE: 64.1111

COIL: 0.5608

CONS_SCORE: 0.6182

DSS_SCORE: 0.5555

HELIX: 0.0929

FCONS_SCORE: 1.0453

RIG_SCORE: 0.762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R64K	DO230849	AML	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.7237
p.V70L	DO222497	BTCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO222867	BTCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO222857	BTCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO230522	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO230986	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO52354	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO231096	LUSC	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO230463	PACA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO51465	PACA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO35406	PACA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO229167	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO229103	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO229211	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.V70L	DO231338	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5654
p.R74L	DO229034	LICA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.25
p.G55S	DO50894	LICA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.1111
p.G55S	DO229103	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.1111
p.R64G	DO229133	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.7568
p.V71I	DO229180	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.5965
p.S68G	DO229229	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.6993
p.P59S	DO229221	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.2222
p.G57D	DO229242	THCA	ICGC	KRTALSKVV	DEG_APCC_DBOX_1	0.1667
p.A66S	SIDM01242	Melanoma	GDSC	KRTALSKVV	DEG_APCC_DBOX_1	0.6477
p.A66S	SIDM00243	Other Solid Cancers	GDSC	KRTALSKVV	DEG_APCC_DBOX_1	0.6477
p.E61D	ACH-000371	Lymphoma	CCLE	KRTALSKVV	DEG_APCC_DBOX_1	0.2778
p.G55R	ACH-001344	Neuroblastoma	CCLE	KRTALSKVV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_APCC_DBOX_1	63:71	KRTALSKVV	APC,CDC20,FZR1	0.7136	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRTALSKVV

Degron related mutations and impact score

Drug responses associated with UPF3A mutations

All proteins holding degron of KRTALSKVV