DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
GREKLSALE
Uniprot ID:
Q9H1J1
Source protein:
Regulator of nonsense transcripts 3A
Source gene:
UPF3A
Class:
DEG_APCC_DBOX_1
Location:
22:30
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9333
ASA_SCORE:
84.5556
COIL:
0.5254
CONS_SCORE:
0.4511
DSS_SCORE:
0.6195
HELIX:
0.4211
FCONS_SCORE:
1.0863
RIG_SCORE:
0.6885
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A17S
DO50921
LICA
ICGC
GREKLSALE
DEG_APCC_DBOX_1
0.1944
p.L26M
DO229216
THCA
ICGC
GREKLSALE
DEG_APCC_DBOX_1
0.711
Drug responses associated with UPF3A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GREKLSALE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H1J1
Regulator of nonsense transcripts 3A
DEG_APCC_DBOX_1
22:30
GREKLSALE
APC,CDC20,FZR1
0.9333
More...