DegronMD - Q9HCI5(MAGEE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G195E	TCGA-06-5416	GBM	TCGA	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.25
p.G195E	DO10880	GBM	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.25
p.T191N	TCGA-34-5240	LUSC	TCGA	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.7055
p.T191N	DO26563	LUSC	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.7055
p.D193N	TCGA-50-5936	LUAD	TCGA	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.3056
p.D193N	DO24237	LUAD	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.3056
p.E158D	TCGA-A5-A1OF	UCEC	TCGA	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.E158D	DO42568	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.P141S	TCGA-AX-A2HG	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.6752
p.P141S	DO41337	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.6752
p.P160L	TCGA-CN-6021	HNSC	TCGA	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6471
p.P160L	DO15847	HNSC	ICGC	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6471
p.P160L	SIDM01303	Esophageal Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6471
p.G195R	TCGA-CV-7568	HNSC	TCGA	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.25
p.G195R	DO14160	HNSC	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.25
p.S133P	TCGA-F4-6570	COAD	TCGA	PPTSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1111
p.S133P	DO10443	COAD	ICGC	PPTSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1111
p.S185N	TCGA-FI-A2D5	UCEC	TCGA	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.7069
p.S185N	DO41331	UCEC	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.7069
p.S163Y	TCGA-IR-A3LF	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.712
p.S163Y	DO44279	CESC	ICGC	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.712
p.V176M	TCGA-VQ-A8P2	STAD	TCGA	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.1667
p.V176M	DO51761	STAD	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.1667
p.P190L	DO222676	BTCA	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.7582
p.P190L	DO23098	LINC	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.7582
p.T179I	DO229005	COCA	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.25
p.T179I	DO51962	PRAD	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation rewiring degron network	0.25
p.V188L	DO229025	LICA	ICGC	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.5654
p.G169V	DO229027	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1667
p.P154R	ACH-000019	Breast Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0833
p.P154R	ACH-000019	Breast Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.P154R	ACH-000028	Breast Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0833
p.P154R	ACH-000028	Breast Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.G183R	ACH-000851	Lung Cancer	CCLE	EGPSTSVVPTP	DEG_COP1_1	182:192	Mutation altering degron motif	0.6457

Kaplan plot for MAGEE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGEE1

UniProt ID: Q9HCI5

Entrez ID: 57692

Protein name: Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGEE1 in