DegronMD

Uniprot ID: Q9HCI5

Source protein: Melanoma-associated antigen E1

Source gene: MAGEE1

Class: DEG_COP1_1

Location: 182:192

E3 ligase: COP1

DEGRON score: 0.7889

ASA_SCORE: 90.7273

COIL: 0.9754

CONS_SCORE: 0.4085

DSS_SCORE: 0.7234

HELIX: 0.0089

FCONS_SCORE: 0.9788

RIG_SCORE: 0.6093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G195E	TCGA-06-5416	GBM	TCGA	EGPSTSVVPTP	DEG_COP1_1	0.25
p.G195E	DO10880	GBM	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.25
p.T191N	TCGA-34-5240	LUSC	TCGA	EGPSTSVVPTP	DEG_COP1_1	0.7055
p.T191N	DO26563	LUSC	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.7055
p.D193N	TCGA-50-5936	LUAD	TCGA	EGPSTSVVPTP	DEG_COP1_1	0.3056
p.D193N	DO24237	LUAD	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.3056
p.G195R	TCGA-CV-7568	HNSC	TCGA	EGPSTSVVPTP	DEG_COP1_1	0.25
p.G195R	DO14160	HNSC	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.25
p.S185N	TCGA-FI-A2D5	UCEC	TCGA	EGPSTSVVPTP	DEG_COP1_1	0.7069
p.S185N	DO41331	UCEC	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.7069
p.V176M	TCGA-VQ-A8P2	STAD	TCGA	EGPSTSVVPTP	DEG_COP1_1	0.1667
p.V176M	DO51761	STAD	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.1667
p.P190L	DO222676	BTCA	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.7582
p.P190L	DO23098	LINC	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.7582
p.T179I	DO229005	COCA	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.25
p.T179I	DO51962	PRAD	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.25
p.V188L	DO229025	LICA	ICGC	EGPSTSVVPTP	DEG_COP1_1	0.5654
p.G183R	ACH-000851	Lung Cancer	CCLE	EGPSTSVVPTP	DEG_COP1_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCI5	Melanoma-associated antigen E1	DEG_COP1_1	182:192	EGPSTSVVPTP	COP1	0.7889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons