DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_SPOP_SBC_1

Location: 462:466

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 80.64

COIL: 0.969

CONS_SCORE: 0.4315

DSS_SCORE: 0.7262

HELIX: 0.0146

FCONS_SCORE: 1.0862

RIG_SCORE: 0.5139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P453H	TCGA-86-A4JF	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0833
p.P453H	DO45317	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.S466N	TCGA-AA-A00N	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7069
p.S466N	DO9876	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7069
p.S466N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7069
p.S466N	ACH-002222	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	0.7069
p.S466N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.7069
p.S471N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1944
p.S471N	ACH-000981	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	0.1944
p.S471N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.1944
p.S460C	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	0.2778
p.S460C	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.2778
p.P462T	SIDM00213	Thyroid Gland Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7031
p.P462T	ACH-000903	Thyroid Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.7031
p.P462T	FTC-133	thyroid	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons