DegronMD - Q9UKU6(TRHDE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T120M	TCGA-14-0871	GBM	TCGA	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7423
p.T120M	DO12640	GBM	ICGC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7423
p.R130L	TCGA-BF-A1Q0	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.0833
p.R130L	DO47374	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.0833
p.E128K	TCGA-EB-A5UL	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.1389
p.E128K	DO47601	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.1389
p.E129Q	TCGA-ZF-AA51	BLCA	TCGA	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.1111
p.E129Q	DO219093	BLCA	ICGC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.1111
p.A111V	SIDM01305	Colorectal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.1667
p.S121L	SIDM00353	Other Sarcomas	GDSC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7667
p.S121L	ACH-000505	Sarcoma	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7667
p.S121L	RKN	ovary	COSMIC	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation altering degron motif	0.7667
p.V114G	ACH-000174	Thyroid Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-000347	Pancreatic Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-000708	Colon/Colorectal Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-000979	Prostate Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-002102	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-002242	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-002267	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25
p.V114G	ACH-002295	Head and Neck Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	117:121	Mutation rewiring degron network	0.25

Kaplan plot for TRHDE in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRHDE

UniProt ID: Q9UKU6

Entrez ID: 29953

Protein name: Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRHDE in