DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_SCF_FBW7_1

Location: 381:387

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 112.4143

COIL: 0.9616

CONS_SCORE: 0.4344

DSS_SCORE: 0.7971

HELIX: 0.016

FCONS_SCORE: 1.1454

RIG_SCORE: 0.5546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E377Q	TCGA-21-5783	LUSC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.2222
p.E377Q	DO27437	LUSC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.2222
p.R390Q	TCGA-2W-A8YY	CESC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.R390Q	DO223732	CESC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.R390Q	SIDM00282	Colorectal Carcinoma	GDSC	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.R390Q	ACH-000998	Colon/Colorectal Cancer	CCLE	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.R390Q	CW-2	large_intestine	COSMIC	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.G378E	TCGA-AP-A1DK	UCEC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.G378E	DO42033	UCEC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.R388H	TCGA-DM-A280	COAD	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.3056
p.R388H	DO8256	COAD	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.3056
p.P389H	TCGA-DU-6392	LGG	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.2778
p.P389H	DO22237	LGG	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.2778
p.G378R	TCGA-EE-A29E	SKCM	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.G378R	DO37831	SKCM	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.25
p.G380R	TCGA-FD-A3N5	BLCA	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.3056
p.G380R	DO639	BLCA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.3056
p.R374Q	TCGA-JW-A5VL	CESC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	0.1389
p.R374Q	DO49976	CESC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.1389
p.R388L	DO228976	LICA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.3056
p.S387I	DO229037	LICA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.7341
p.R386Q	DO220883	MELA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.6218
p.R388C	DO51541	PACA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	0.3056
p.P389S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQTPRRS	DEG_SCF_FBW7_1	0.2778
p.G380D	ACH-001524	Skin Cancer	CCLE	PQTPRRS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SCF_FBW7_1	381:387	PQTPRRS	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons