DegronMD

Uniprot ID: Q7Z6G8

Source protein: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Source gene: ANKS1B

Class: DEG_MDM2_SWIB_1

Location: 776:783

E3 ligase: MDM2

DEGRON score: 0.7227

ASA_SCORE: 73.4125

COIL: 0.3466

CONS_SCORE: 0.3924

DSS_SCORE: 0.5316

HELIX: 0.644

FCONS_SCORE: 1.0233

RIG_SCORE: 0.7652

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I783T	TCGA-RC-A7SK	LIHC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.7078
p.I783T	DO52314	LIHC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.7078
p.W780C	SIDM00217	Colorectal Carcinoma	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.7
p.W780C	SNU-1040	large_intestine	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.7
p.S778W	TCGA-FD-A6TC	BLCA	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.6763
p.S778W	DO49755	BLCA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6763
p.S778L	TCGA-AP-A0LM	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.6556
p.S778L	DO51506	PACA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6556
p.S778L	DO43306	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6556
p.T777A	TCGA-AA-A01P	COAD	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.6028
p.T777A	DO8642	COAD	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6028
p.T777I	ACH-000901	Lung Cancer	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.5966
p.E782D	SIDM00487	Colorectal Carcinoma	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.5647
p.E782D	CCK-81	large_intestine	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.5647
p.E779Q	TCGA-EY-A1GS	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.5633
p.E779Q	DO43162	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.5633
p.D784G	ACH-001991	Primary	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.3056
p.K785N	TCGA-F5-6814	READ	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.2778
p.K785N	DO36556	READ	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.2778
p.T773A	DO220881	MELA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.25
p.M787I	SIDM00794	Other Solid Cancers	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.2222
p.M787I	ACH-001442	Skin Cancer	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.2222
p.M787I	A388	skin	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.2222
p.E771K	DO231022	LUSC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1944
p.S770Y	TCGA-85-8070	LUSC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_MDM2_SWIB_1	776:783	FTSEWEEI	MDM2	0.7227	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons