DegronMD

Uniprot ID: Q7Z6G8

Source protein: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Source gene: ANKS1B

Class: DEG_MDM2_SWIB_1

Location: 776:783

E3 ligase: MDM2

DEGRON score: 0.7227

ASA_SCORE: 73.4125

COIL: 0.3466

CONS_SCORE: 0.3924

DSS_SCORE: 0.5316

HELIX: 0.644

FCONS_SCORE: 1.0233

RIG_SCORE: 0.7652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S770Y	TCGA-85-8070	LUSC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.1667
p.S770Y	DO26581	LUSC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1667
p.T777A	TCGA-AA-A01P	COAD	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.6028
p.T777A	DO8642	COAD	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6028
p.D791Y	TCGA-AP-A059	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.1111
p.D791Y	TCGA-BR-8487	STAD	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.1111
p.D791Y	DO47867	STAD	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1111
p.D791Y	DO41361	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1111
p.S778L	TCGA-AP-A0LM	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.6556
p.S778L	DO51506	PACA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6556
p.S778L	DO43306	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6556
p.E779Q	TCGA-EY-A1GS	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.5633
p.E779Q	DO43162	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.5633
p.K785N	TCGA-F5-6814	READ	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.2778
p.K785N	DO36556	READ	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.2778
p.S778W	TCGA-FD-A6TC	BLCA	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.6763
p.S778W	DO49755	BLCA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.6763
p.I783T	TCGA-RC-A7SK	LIHC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	0.7078
p.I783T	DO52314	LIHC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.7078
p.E771K	DO231022	LUSC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1944
p.T773A	DO220881	MELA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	0.25
p.V792A	SIDM00855	Other Sarcomas	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.0833
p.E782D	SIDM00487	Colorectal Carcinoma	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.5647
p.E782D	CCK-81	large_intestine	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.5647
p.M787I	SIDM00794	Other Solid Cancers	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.2222
p.M787I	ACH-001442	Skin Cancer	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.2222
p.M787I	A388	skin	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.2222
p.I790M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1389
p.I790M	ACH-002275	Leukemia	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.1389
p.I790M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.1389
p.W780C	SIDM00217	Colorectal Carcinoma	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	0.7
p.W780C	SNU-1040	large_intestine	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	0.7
p.T777I	ACH-000901	Lung Cancer	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.5966
p.D784G	ACH-001991	Primary	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FTSEWEEI

Degron related mutations and impact score

Drug responses associated with ANKS1B mutations

All proteins holding degron of FTSEWEEI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_MDM2_SWIB_1	776:783	FTSEWEEI	MDM2	0.7227	More...