DegronMD

Uniprot ID: Q7Z6G8

Source protein: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Source gene: ANKS1B

Class: DEG_SCF_FBW7_1

Location: 502:507

E3 ligase: FBXW7

DEGRON score: 0.9505

ASA_SCORE: 77.6

COIL: 0.9667

CONS_SCORE: 0.387

DSS_SCORE: 0.7528

HELIX: 0.0133

FCONS_SCORE: 1.0244

RIG_SCORE: 0.5555

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P511A	TCGA-34-5236	LUSC	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.2222
p.P511A	DO26778	LUSC	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.2222
p.N494K	TCGA-46-6026	LUSC	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.1111
p.N494K	DO26740	LUSC	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.1111
p.A514P	TCGA-50-5066	LUAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.1389
p.A514P	DO25040	LUAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.1389
p.S498R	TCGA-67-3770	LUAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.2222
p.S498R	DO23932	LUAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.2222
p.D505Y	TCGA-94-A5I6	LUSC	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.6214
p.D505Y	DO219176	LUSC	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.6214
p.R496K	TCGA-EB-A551	SKCM	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.1667
p.R496K	DO47453	SKCM	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.1667
p.D505G	TCGA-HU-A4H3	STAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.6087
p.D505G	DO47903	STAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.6087
p.T500I	TCGA-P4-AAVL	KIRP	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.2778
p.T500I	DO219694	KIRP	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.2778
p.A514T	TCGA-XK-AAIW	PRAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	0.1389
p.A514T	DO51407	PRAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.1389
p.A514T	SIDM02021	Esophageal Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	0.1389
p.T503A	DO222542	MELA	ICGC	PTPDCS	DEG_SCF_FBW7_1	0.7139
p.P502T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	0.7031
p.P502T	ACH-002176	Lung Cancer	CCLE	PTPDCS	DEG_SCF_FBW7_1	0.7031
p.P502T	NCI-H748	lung	COSMIC	PTPDCS	DEG_SCF_FBW7_1	0.7031
p.R499S	SIDM00487	Colorectal Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	0.25
p.R499S	CCK-81	large_intestine	COSMIC	PTPDCS	DEG_SCF_FBW7_1	0.25
p.E496K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	0.1667
p.E496K	NCI-H2342	lung	COSMIC	PTPDCS	DEG_SCF_FBW7_1	0.1667
p.I506V	BICR78	upper_aerodigestive_tract	COSMIC	PTPDCS	DEG_SCF_FBW7_1	0.7076
p.R514H	NCI-H64	lung	COSMIC	PTPDCS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPDCS

Degron related mutations and impact score

Drug responses associated with ANKS1B mutations

All proteins holding degron of PTPDCS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SCF_FBW7_1	502:507	PTPDCS	FBXW7	0.9505	More...