DegronMD

Uniprot ID: Q13439

Source protein: Golgin subfamily A member 4

Source gene: GOLGA4

Class: DEG_SPOP_SBC_1

Location: 94:98

E3 ligase: SPOP

DEGRON score: 0.9897

ASA_SCORE: 92.88

COIL: 0.7032

CONS_SCORE: 0.6741

DSS_SCORE: 0.432

HELIX: 0.2574

FCONS_SCORE: 1.0481

RIG_SCORE: 0.6881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V94M	TCGA-AP-A059	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.7208
p.R108W	TCGA-AP-A059	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.D108H	DO51884	BLCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.V94L	DO222404	BTCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6765
p.S87F	DO51642	CESC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.5833
p.R95Q	DO7855	COAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6218
p.R95Q	DO42793	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6218
p.R95L	DO229041	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.7316
p.S92C	DO41193	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.7222
p.R86W	DO41361	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.S98Y	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.8231
p.R93H	LoVo	large_intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons