DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9817:9821

E3 ligase: SPOP

DEGRON score: 0.8575

ASA_SCORE: 97.22

COIL: 0.7808

CONS_SCORE: 0

DSS_SCORE: 0.5337

HELIX: 0.0226

FCONS_SCORE: 0

RIG_SCORE: 0.6638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9810T	TCGA-23-2084	OV	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.S9810T	DO30310	OV	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.H9827Y	TCGA-C5-A3HF	CESC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1667
p.H9827Y	DO49015	CESC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.P9808L	TCGA-CC-A8HT	LIHC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0833
p.P9808L	DO52187	LIHC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.H9807Y	TCGA-D3-A8GV	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807Y	TCGA-D9-A3Z1	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807Y	TCGA-EE-A29E	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807Y	DO218863	SKCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807Y	DO37831	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807Y	DO38105	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807Y	DO219477	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.A9815D	TCGA-FJ-A3ZE	BLCA	TCGA	VRTSS	DEG_SPOP_SBC_1	0.2778
p.A9815D	DO484	BLCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.S9828F	TCGA-KK-A6E7	PRAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.S9828F	DO51362	PRAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.S9822Y	DO222884	COCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.T9819S	DO234422	ESAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6005
p.H9824N	DO229034	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.25
p.S9822F	DO220877	MELA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.R9818K	DO220882	MELA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6126
p.S9820F	SIDM00185	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.9093
p.S9820F	ACH-002152	Skin Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.9093
p.S9820F	LB2518-MEL	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.9093
p.H9807N	SIDM00534	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807N	ACH-000986	Colon/Colorectal Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.0556
p.H9807N	HT-115	large_intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VRTSS