DegronMD - Q8TDG4(HELQ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I120V	TCGA-AO-A128	BRCA	TCGA	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.I120V	DO5326	BRCA	ICGC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.0556
p.R262I	TCGA-AP-A1DV	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1944
p.R262I	DO43186	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1944
p.N246K	TCGA-BS-A0UF	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1389
p.N246K	DO41488	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1389
p.D102G	TCGA-FI-A2D5	UCEC	TCGA	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.25
p.D102G	DO41331	UCEC	ICGC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.25
p.E116G	TCGA-FS-A1ZT	SKCM	TCGA	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.E116G	DO37468	SKCM	ICGC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1667
p.D112G	TCGA-HZ-8001	PAAD	TCGA	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2778
p.D112G	DO32796	PAAD	ICGC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2778
p.M259V	DO222973	BTCA	ICGC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.2778
p.P243S	DO223419	CLLE	ICGC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.0556
p.N246S	DO234192	ESAD	ICGC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1389
p.Y111C	DO233081	GACA	ICGC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.3056
p.D106E	DO229026	LICA	ICGC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation altering degron motif	0.5647
p.S251P	SIDM01314	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.2778
p.D247N	SIDM00319	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1667
p.D247N	ACH-001704	Skin Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1667
p.D247N	VMRC-MELG	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.1667
p.S103N	SIDM00151	Ovarian Carcinoma	GDSC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2778
p.S103N	ACH-000966	Ovarian Cancer	CCLE	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2778
p.S103N	IGROV-1	ovary	COSMIC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.2778
p.D258Y	SIDM00963	Breast Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.3056
p.D258Y	ACH-000927	Breast Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.3056
p.D258Y	BT-474	breast	COSMIC	VRTSS	DEG_SPOP_SBC_1	253:257	Mutation rewiring degron network	0.3056
p.P100S	SIDM00068	Colorectal Carcinoma	GDSC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944
p.P100S	GEO	large intestine	COSMIC	VDMFGD	LIG_APCC_ABBA_1	105:110	Mutation rewiring degron network	0.1944

Kaplan plot for HELQ in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HELQ

UniProt ID: Q8TDG4

Entrez ID: 113510

Protein name: Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HELQ in