DegronMD

Uniprot ID: Q8TDG4

Source protein: Helicase POLQ-like

Source gene: HELQ

Class: LIG_APCC_ABBA_1

Location: 105:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7093

ASA_SCORE: 64.9333

COIL: 0.5812

CONS_SCORE: 0.3124

DSS_SCORE: 0.5671

HELIX: 0.3085

FCONS_SCORE: 1.1178

RIG_SCORE: 0.7565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I120V	TCGA-AO-A128	BRCA	TCGA	VDMFGD	LIG_APCC_ABBA_1	0.0556
p.I120V	DO5326	BRCA	ICGC	VDMFGD	LIG_APCC_ABBA_1	0.0556
p.D102G	TCGA-FI-A2D5	UCEC	TCGA	VDMFGD	LIG_APCC_ABBA_1	0.25
p.D102G	DO41331	UCEC	ICGC	VDMFGD	LIG_APCC_ABBA_1	0.25
p.E116G	TCGA-FS-A1ZT	SKCM	TCGA	VDMFGD	LIG_APCC_ABBA_1	0.1667
p.E116G	DO37468	SKCM	ICGC	VDMFGD	LIG_APCC_ABBA_1	0.1667
p.D112G	TCGA-HZ-8001	PAAD	TCGA	VDMFGD	LIG_APCC_ABBA_1	0.2778
p.D112G	DO32796	PAAD	ICGC	VDMFGD	LIG_APCC_ABBA_1	0.2778
p.Y111C	DO233081	GACA	ICGC	VDMFGD	LIG_APCC_ABBA_1	0.3056
p.D106E	DO229026	LICA	ICGC	VDMFGD	LIG_APCC_ABBA_1	0.5647
p.S103N	SIDM00151	Ovarian Carcinoma	GDSC	VDMFGD	LIG_APCC_ABBA_1	0.2778
p.S103N	ACH-000966	Ovarian Cancer	CCLE	VDMFGD	LIG_APCC_ABBA_1	0.2778
p.S103N	IGROV-1	ovary	COSMIC	VDMFGD	LIG_APCC_ABBA_1	0.2778
p.P100S	SIDM00068	Colorectal Carcinoma	GDSC	VDMFGD	LIG_APCC_ABBA_1	0.1944
p.P100S	GEO	large_intestine	COSMIC	VDMFGD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDG4	Helicase POLQ-like	LIG_APCC_ABBA_1	105:110	VDMFGD	APC,CDC20,FZR1	0.7093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons