DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRTSS
Uniprot ID:
Q5T0Z8
Source protein:
Uncharacterized protein C6orf132
Source gene:
C6orf132
Class:
DEG_SPOP_SBC_1
Location:
310:314
E3 ligase:
SPOP
DEGRON score:
0.9965
ASA_SCORE:
103.92
COIL:
0.9578
CONS_SCORE:
0.8041
DSS_SCORE:
0.6779
HELIX:
0.0174
FCONS_SCORE:
1.0927
RIG_SCORE:
0.6526
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R311M
DO229268
THCA
ICGC
VRTSS
DEG_SPOP_SBC_1
0.7521
p.S313L
ACH-000993
Endometrial/Uterine Cancer
CCLE
VRTSS
DEG_SPOP_SBC_1
0.7667
Drug responses associated with C6orf132 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13439
Golgin subfamily A member 4
DEG_SPOP_SBC_1
94:98
VRTSS
SPOP
0.9897
More...
Q7Z6G8
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
DEG_SPOP_SBC_1
376:380
VRTSS
SPOP
0.996
More...
Q8TDG4
Helicase POLQ-like
DEG_SPOP_SBC_1
253:257
VRTSS
SPOP
0.5893
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
9817:9821
VRTSS
SPOP
0.8575
More...
Q8WY36
HMG box transcription factor BBX
DEG_SPOP_SBC_1
511:515
VRTSS
SPOP
0.9823
More...
Q9BY84
Dual specificity protein phosphatase 16
DEG_SPOP_SBC_1
487:491
VRTSS
SPOP
0.7285
More...
Q8TE59
A disintegrin and metalloproteinase with thrombospondin motifs 19
DEG_SPOP_SBC_1
702:706
VRTSS
SPOP
0.6468
More...
Q5T0Z8
Uncharacterized protein C6orf132
DEG_SPOP_SBC_1
310:314
VRTSS
SPOP
0.9965
More...
Q86VQ1
Glucocorticoid-induced transcript 1 protein
DEG_SPOP_SBC_1
161:165
VRTSS
SPOP
0.7782
More...