DegronMD - Q13439(GOLGA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R99Q	TCGA-AD-5900	COAD	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7329
p.R99Q	TCGA-AN-A046	BRCA	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7329
p.R99Q	SIDM00534	Colorectal Carcinoma	GDSC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7329
p.R99Q	ACH-000986	Colon/Colorectal Cancer	CCLE	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7329
p.R99Q	HT-115	large intestine	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7329
p.A2164V	TCGA-AP-A054	UCEC	TCGA	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.2778
p.V94M	TCGA-AP-A059	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.7208
p.R108W	TCGA-AP-A059	UCEC	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.2778
p.R108W	TCGA-AP-A059	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.0556
p.S114C	TCGA-AX-A2H4	UCEC	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.1111
p.N2161D	TCGA-CA-6718	COAD	TCGA	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1944
p.S109F	TCGA-VS-A9UH	CESC	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.25
p.D108H	DO51884	BLCA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.2778
p.D108H	DO51884	BLCA	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.0556
p.E2174K	DO1285	BRCA	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.25
p.E2174K	DO222421	BTCA	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.25
p.E2174K	DO41020	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.25
p.E2174K	DO41644	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.25
p.E2174K	DO43907	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.25
p.V94L	DO222404	BTCA	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.6765
p.N103S	DO222404	BTCA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.5958
p.S87F	DO51642	CESC	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation blocking phosphorylation signal	0.5833
p.R95Q	DO7855	COAD	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.6218
p.R95Q	DO42793	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.6218
p.D106N	DO52432	COCA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.5821
p.S2167L	DO14274	HNSC	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation altering degron motif	0.7667
p.S113I	DO229026	LICA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.1389
p.G2159V	DO229038	LICA	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1389
p.R95L	DO229041	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.7316
p.S109R	DO50291	SKCM	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.25
p.S92C	DO41193	UCEC	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation blocking phosphorylation signal	0.6111
p.S92C	DO41193	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation blocking phosphorylation signal	0.7222
p.R2179Q	DO41133	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1111
p.R104Q	DO41488	UCEC	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.6218
p.R86W	DO41361	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.1111
p.T2179M	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1111
p.T2179M	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1111
p.T2179M	SIDM00274	Gastric Carcinoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1111
p.T2179M	SIDM01446	Glioblastoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation rewiring degron network	0.1111
p.P101L	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7582
p.P101L	NCI-H1666	lung	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7582
p.F2169I	ACH-000298	Lung Cancer	CCLE	VSLFGE	LIG_APCC_ABBA_1	2166:2171	Mutation altering degron motif	0.7415
p.P101Q	ACH-001413	Bladder Cancer	CCLE	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.7035
p.S98Y	K-562	haematopoietic and lymphoid tissue	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.712
p.S98Y	K-562	haematopoietic and lymphoid tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation altering degron motif	0.8231
p.R100H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation altering degron motif	0.8244
p.R93H	LoVo	large intestine	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	98:106	Mutation rewiring degron network	0.1944
p.R93H	LoVo	large intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	94:98	Mutation rewiring degron network	0.3056

Kaplan plot for GOLGA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GOLGA4

UniProt ID: Q13439

Entrez ID: 2803

Protein name: Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GOLGA4 in