DegronMD

Uniprot ID: Q13439

Source protein: Golgin subfamily A member 4

Source gene: GOLGA4

Class: LIG_APCC_ABBA_1

Location: 2166:2171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7449

ASA_SCORE: 99.25

COIL: 0.8187

CONS_SCORE: 0.4126

DSS_SCORE: 0.1644

HELIX: 0.1795

FCONS_SCORE: 0.6321

RIG_SCORE: 0.8238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2164V	TCGA-AP-A054	UCEC	TCGA	VSLFGE	LIG_APCC_ABBA_1	0.2778
p.N2161D	TCGA-CA-6718	COAD	TCGA	VSLFGE	LIG_APCC_ABBA_1	0.1944
p.E2174K	DO1285	BRCA	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.25
p.E2174K	DO222421	BTCA	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.25
p.E2174K	DO41020	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.25
p.E2174K	DO41644	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.25
p.E2174K	DO43907	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.25
p.S2167L	DO14274	HNSC	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.7667
p.G2159V	DO229038	LICA	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.1389
p.R2179Q	DO41133	UCEC	ICGC	VSLFGE	LIG_APCC_ABBA_1	0.1111
p.T2179M	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	0.1111
p.T2179M	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	0.1111
p.T2179M	SIDM00274	Gastric Carcinoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	0.1111
p.T2179M	SIDM01446	Glioblastoma	GDSC	VSLFGE	LIG_APCC_ABBA_1	0.1111
p.F2169I	ACH-000298	Lung Cancer	CCLE	VSLFGE	LIG_APCC_ABBA_1	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	LIG_APCC_ABBA_1	2166:2171	VSLFGE	APC,CDC20,FZR1	0.7449	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons