DegronMD

Uniprot ID: Q13439

Source protein: Golgin subfamily A member 4

Source gene: GOLGA4

Class: DEG_APCC_DBOX_1

Location: 98:106

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9982

ASA_SCORE: 103.5

COIL: 0.7186

CONS_SCORE: 0.6631

DSS_SCORE: 0.4619

HELIX: 0.2441

FCONS_SCORE: 1.022

RIG_SCORE: 0.6816

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R99Q	TCGA-AD-5900	COAD	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	0.7329
p.R99Q	TCGA-AN-A046	BRCA	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	0.7329
p.R99Q	SIDM00534	Colorectal Carcinoma	GDSC	SRESLNRLD	DEG_APCC_DBOX_1	0.7329
p.R99Q	ACH-000986	Colon/Colorectal Cancer	CCLE	SRESLNRLD	DEG_APCC_DBOX_1	0.7329
p.R99Q	HT-115	large_intestine	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	0.7329
p.R108W	TCGA-AP-A059	UCEC	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	0.2778
p.S114C	TCGA-AX-A2H4	UCEC	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	0.1111
p.S109F	TCGA-VS-A9UH	CESC	TCGA	SRESLNRLD	DEG_APCC_DBOX_1	0.25
p.D108H	DO51884	BLCA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.2778
p.N103S	DO222404	BTCA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.5958
p.D106N	DO52432	COCA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.5821
p.S113I	DO229026	LICA	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.1389
p.S109R	DO50291	SKCM	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.25
p.S92C	DO41193	UCEC	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.6111
p.R104Q	DO41488	UCEC	ICGC	SRESLNRLD	DEG_APCC_DBOX_1	0.6218
p.P101L	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	SRESLNRLD	DEG_APCC_DBOX_1	0.7582
p.P101L	NCI-H1666	lung	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	0.7582
p.P101Q	ACH-001413	Bladder Cancer	CCLE	SRESLNRLD	DEG_APCC_DBOX_1	0.7035
p.S98Y	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	0.712
p.R100H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	0.8244
p.R93H	LoVo	large_intestine	COSMIC	SRESLNRLD	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_APCC_DBOX_1	98:106	SRESLNRLD	APC,CDC20,FZR1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons