DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPGGGSYSLQP
Uniprot ID:
Q9C0H5
Source protein:
Rho GTPase-activating protein 39
Source gene:
ARHGAP39
Class:
CBL_PTK
Location:
421:431
E3 ligase:
CBL
DEGRON score:
0.9989
ASA_SCORE:
75.5273
COIL:
0.9122
CONS_SCORE:
0.316
DSS_SCORE:
0.6084
HELIX:
0.041
FCONS_SCORE:
1.0343
RIG_SCORE:
0.5908
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R440L
TCGA-22-4591
LUSC
TCGA
NPGGGSYSLQP
CBL_PTK
0.0833
p.R440L
DO26620
LUSC
ICGC
NPGGGSYSLQP
CBL_PTK
0.0833
p.G423S
TCGA-37-4132
LUSC
TCGA
NPGGGSYSLQP
CBL_PTK
0.5882
p.G423S
DO26528
LUSC
ICGC
NPGGGSYSLQP
CBL_PTK
0.5882
p.G423S
SIDM00216
Colorectal Carcinoma
GDSC
NPGGGSYSLQP
CBL_PTK
0.5882
p.G423S
ACH-000989
Colon/Colorectal Cancer
CCLE
NPGGGSYSLQP
CBL_PTK
0.5882
p.S428F
TCGA-D3-A2JL
SKCM
TCGA
NPGGGSYSLQP
CBL_PTK
0.7982
p.S428F
DO47278
SKCM
ICGC
NPGGGSYSLQP
CBL_PTK
0.7982
p.S426L
TCGA-FS-A4F9
SKCM
TCGA
NPGGGSYSLQP
CBL_PTK
0.6556
p.S426L
DO38069
SKCM
ICGC
NPGGGSYSLQP
CBL_PTK
0.6556
p.Y418H
DO228246
BRCA
ICGC
NPGGGSYSLQP
CBL_PTK
0.25
p.G425D
DO233613
GACA
ICGC
NPGGGSYSLQP
CBL_PTK
0.6087
p.A419V
DO233888
GACA
ICGC
NPGGGSYSLQP
CBL_PTK
0.2778
p.R411C
DO233855
GACA
ICGC
NPGGGSYSLQP
CBL_PTK
0.0556
p.P422L
DO220890
MELA
ICGC
NPGGGSYSLQP
CBL_PTK
0.6471
p.R415Q
DO229542
UTCA
ICGC
NPGGGSYSLQP
CBL_PTK
0.1667
p.G424S
SIDM01007
T-Lymphoblastic Leukemia
GDSC
NPGGGSYSLQP
CBL_PTK
0.5882
p.Y418C
SIDM01045
Endometrial Carcinoma
GDSC
NPGGGSYSLQP
CBL_PTK
0.25
p.Y418C
ACH-000978
Endometrial/Uterine Cancer
CCLE
NPGGGSYSLQP
CBL_PTK
0.25
p.S432N
ACH-000893
Lung Cancer
CCLE
NPGGGSYSLQP
CBL_PTK
0.75
Drug responses associated with ARHGAP39 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPGGGSYSLQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0H5
Rho GTPase-activating protein 39
CBL_PTK
421:431
NPGGGSYSLQP
CBL
0.9989
More...