DegronMD - Q33E94(RFX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q580K	TCGA-78-8640	LUAD	TCGA	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.6944
p.G572V	TCGA-A5-A0G2	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.S696N	TCGA-A5-A1OF	UCEC	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.1944
p.T716M	TCGA-A6-6781	COAD	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.0833
p.T716M	TCGA-NH-A5IV	COAD	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.0833
p.P697L	TCGA-AJ-A3EK	UCEC	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2222
p.P697L	TCGA-EE-A181	SKCM	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2222
p.P697L	SIDM01045	Endometrial Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2222
p.P697L	EN	endometrium	COSMIC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2222
p.V594I	TCGA-BA-A6DL	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0556
p.G572W	TCGA-BH-A0AU	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.R717C	TCGA-CF-A3MF	BLCA	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.0556
p.P582S	TCGA-D3-A3MR	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.6752
p.D709G	TCGA-EI-6917	READ	TCGA	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2778
p.Q579K	TCGA-NC-A5HL	LUSC	TCGA	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.3056
p.A587T	DO233882	GACA	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.25
p.L572M	DO22237	LGG	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.V577F	DO228976	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.25
p.R571I	DO26596	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0833
p.P594L	DO37444	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0556
p.P594L	DO41584	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0556
p.P594L	EN	endometrium	COSMIC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0556
p.R580H	DO40918	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.8244
p.S593N	DO42568	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0833
p.S708C	SIDM02067	Colorectal Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.3056
p.A570D	SIDM01057	Acute Myeloid Leukemia	GDSC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.0556
p.S698C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.25
p.S698C	H513	pleura	COSMIC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.25
p.V699G	SIDM00732	Glioblastoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2778
p.V699G	D-263MG	central nervous system	COSMIC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.2778
p.T692M	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	701:707	Mutation rewiring degron network	0.0833
p.P576Q	RMG-I	ovary	COSMIC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.2222
p.R580C	MKN45	stomach	COSMIC	VPSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.8301

Kaplan plot for RFX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFX4

UniProt ID: Q33E94

Entrez ID: 5992

Protein name: Transcription factor RFX4 (Regulatory factor X 4) (Testis development protein NYD-SP10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFX4 in