DegronMD

Uniprot ID: Q33E94

Source protein: Transcription factor RFX4

Source gene: RFX4

Class: DEG_SCF_FBW7_1

Location: 701:707

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 73.5143

COIL: 0.8466

CONS_SCORE: 0.2237

DSS_SCORE: 0.4827

HELIX: 0.0733

FCONS_SCORE: 0.8045

RIG_SCORE: 0.754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S696N	TCGA-A5-A1OF	UCEC	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.1944
p.T716M	TCGA-A6-6781	COAD	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.0833
p.T716M	TCGA-NH-A5IV	COAD	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.0833
p.P697L	TCGA-AJ-A3EK	UCEC	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.2222
p.P697L	TCGA-EE-A181	SKCM	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.2222
p.P697L	SIDM01045	Endometrial Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	0.2222
p.P697L	EN	endometrium	COSMIC	MYTPLTT	DEG_SCF_FBW7_1	0.2222
p.R717C	TCGA-CF-A3MF	BLCA	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.0556
p.D709G	TCGA-EI-6917	READ	TCGA	MYTPLTT	DEG_SCF_FBW7_1	0.2778
p.S708C	SIDM02067	Colorectal Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	0.3056
p.S698C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	0.25
p.S698C	H513	pleura	COSMIC	MYTPLTT	DEG_SCF_FBW7_1	0.25
p.V699G	SIDM00732	Glioblastoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	0.2778
p.V699G	D-263MG	central_nervous_system	COSMIC	MYTPLTT	DEG_SCF_FBW7_1	0.2778
p.T692M	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	MYTPLTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q33E94	Transcription factor RFX4	DEG_SCF_FBW7_1	701:707	MYTPLTT	FBXW7	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons