DegronMD - P20823(HNF1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P580L	TCGA-2W-A8YY	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.0556
p.S335L	TCGA-56-8304	LUSC	TCGA	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7667
p.S335L	DO219138	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7667
p.R278Q	TCGA-A6-5665	COAD	TCGA	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.1667
p.R278Q	DO9756	COAD	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.1667
p.A586T	TCGA-AA-A01P	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.2222
p.P289A	TCGA-AJ-A2QO	UCEC	TCGA	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6392
p.P289A	DO42177	UCEC	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6392
p.R278W	TCGA-AX-A3FT	UCEC	TCGA	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.1667
p.R278W	DO40801	UCEC	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.1667
p.P580S	TCGA-EB-A5SE	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.0556
p.G292E	TCGA-EE-A2MS	SKCM	TCGA	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.2778
p.G292E	DO37567	SKCM	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.2778
p.P347S	TCGA-EE-A2MS	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.P347S	DO37567	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.G339S	TCGA-EO-A3KX	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2778
p.G339S	DO219774	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2778
p.T346I	TCGA-EY-A1GU	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.T346I	DO41518	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.A326V	TCGA-FI-A2D0	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.A326V	DO43891	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.P340L	TCGA-FW-A3R5	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.P340L	DO222521	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.P340L	DO37406	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.A282T	TCGA-NC-A5HG	LUSC	TCGA	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.2778
p.A282T	DO45448	LUSC	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.2778
p.T285M	DO224811	BRCA	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6312
p.T285M	DO33800	PACA	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6312
p.T285M	ACH-001228		CCLE	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6312
p.P589L	DO223732	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.V342L	DO228971	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.V342L	DO229045	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.A58S	DO229015	LICA	ICGC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6477
p.M283I	DO229015	LICA	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.3056
p.M283I	DO229027	LICA	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.3056
p.G294V	DO229041	LICA	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.2222
p.G330S	DO222632	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.A58V	DO222714	MELA	ICGC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.5825
p.P337L	DO222837	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7582
p.P599L	DO36311	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1944
p.E274K	DO229456	SKCA	ICGC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.0556
p.A593T	DO51291	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.7139
p.G347V	DO223286	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.G326C	DO42480	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.A588T	SIDM00216	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.2778
p.E329Q	SIDM00945	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2222
p.E329Q	ACH-000895	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2222
p.E329Q	CL-34	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.2222
p.G63V	SIDM00507	Other Solid Cancers	GDSC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.G63V	ACH-001490	Lung Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.G63V	COR-L321	NS	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.P43T	SIDM00719	Small Cell Lung Carcinoma	GDSC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.P43T	ACH-001364	Lung Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.P43T	NCI-H345	lung	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.T327I	SIDM00733	Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.T327I	ACH-000525	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.T327I	NCI-H2171	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.G52A	SIDM00878	Breast Carcinoma	GDSC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.3056
p.G52A	SIDM01133	Other Solid Cancers	GDSC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.3056
p.G52A	ACH-000930	Breast Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.3056
p.G52A	NCI-H835	lung	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.3056
p.G52A	HCC1569	breast	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.3056
p.R590Q	SIDM00068	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.7329
p.G288V	SIDM00220	Ovarian Carcinoma	GDSC	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6421
p.P291S	SIDM00861	Ovarian Carcinoma	GDSC	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.3056
p.G51D	SIDM01608	Endometrial Carcinoma	GDSC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.G51D	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.P289L	SIDM01387	Small Cell Lung Carcinoma	GDSC	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6471
p.P289L	ACH-000921	Lung Cancer	CCLE	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.6471
p.A581T	ACH-000989	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.0833
p.G296V	ACH-001111	Lymphoma	CCLE	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.1667
p.T343R	ACH-001853	Bile Duct Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.G296E	ACH-001864	Bile Duct Cancer	CCLE	DTYSGPP	CBL_PTK	284:290	Mutation rewiring degron network	0.1667
p.Q284R	NCI-H2066	lung	COSMIC	DTYSGPP	CBL_PTK	284:290	Mutation altering degron motif	0.7329
p.I45M	HCC202	breast	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1111
p.T336K	GAK	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7306
p.Q59R	NCI-H2066	lung	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNF1A

UniProt ID: P20823

Entrez ID: 6927

Protein name: Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HNF1A in