DegronMD

Uniprot ID: P20823

Source protein: Hepatocyte nuclear factor 1-alpha

Source gene: HNF1A

Class: DEG_APCC_DBOX_1

Location: 53:61

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9715

ASA_SCORE: 81.3556

COIL: 0.8069

CONS_SCORE: 0.2852

DSS_SCORE: 0.6479

HELIX: 0.1108

FCONS_SCORE: 0.8629

RIG_SCORE: 0.6646

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q59R	NCI-H2066	lung	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	0.7329
p.A58S	DO229015	LICA	ICGC	GRGELAELP	DEG_APCC_DBOX_1	0.6477
p.A58V	DO222714	MELA	ICGC	GRGELAELP	DEG_APCC_DBOX_1	0.5825
p.G52A	SIDM00878	Breast Carcinoma	GDSC	GRGELAELP	DEG_APCC_DBOX_1	0.3056
p.G52A	SIDM01133	Other Solid Cancers	GDSC	GRGELAELP	DEG_APCC_DBOX_1	0.3056
p.G52A	ACH-000930	Breast Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	0.3056
p.G52A	NCI-H835	lung	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	0.3056
p.G52A	HCC1569	breast	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	0.3056
p.G63V	SIDM00507	Other Solid Cancers	GDSC	GRGELAELP	DEG_APCC_DBOX_1	0.2778
p.G63V	ACH-001490	Lung Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	0.2778
p.G63V	COR-L321	NS	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	0.2778
p.G51D	SIDM01608	Endometrial Carcinoma	GDSC	GRGELAELP	DEG_APCC_DBOX_1	0.2778
p.G51D	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	0.2778
p.I45M	HCC202	breast	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	0.1111
p.P43T	SIDM00719	Small Cell Lung Carcinoma	GDSC	GRGELAELP	DEG_APCC_DBOX_1	0.0556
p.P43T	ACH-001364	Lung Cancer	CCLE	GRGELAELP	DEG_APCC_DBOX_1	0.0556
p.P43T	NCI-H345	lung	COSMIC	GRGELAELP	DEG_APCC_DBOX_1	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20823	Hepatocyte nuclear factor 1-alpha	DEG_APCC_DBOX_1	53:61	GRGELAELP	APC,CDC20,FZR1	0.9715	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons