DegronMD

Uniprot ID: P20823

Source protein: Hepatocyte nuclear factor 1-alpha

Source gene: HNF1A

Class: DEG_SPOP_SBC_1

Location: 333:337

E3 ligase: SPOP

DEGRON score: 0.9824

ASA_SCORE: 72.1

COIL: 0.919

CONS_SCORE: 0.4262

DSS_SCORE: 0.6205

HELIX: 0.0232

FCONS_SCORE: 0.9193

RIG_SCORE: 0.5937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S335L	TCGA-56-8304	LUSC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.7667
p.S335L	DO219138	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.7667
p.P347S	TCGA-EE-A2MS	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.0556
p.P347S	DO37567	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0556
p.G339S	TCGA-EO-A3KX	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.2778
p.G339S	DO219774	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2778
p.T346I	TCGA-EY-A1GU	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.0833
p.T346I	DO41518	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A326V	TCGA-FI-A2D0	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1389
p.A326V	DO43891	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1389
p.P340L	TCGA-FW-A3R5	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.25
p.P340L	DO222521	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.25
p.P340L	DO37406	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.25
p.V342L	DO228971	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.V342L	DO229045	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.G330S	DO222632	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.25
p.P337L	DO222837	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.7582
p.G347V	DO223286	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0556
p.G326C	DO42480	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1389
p.E329Q	SIDM00945	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.2222
p.E329Q	ACH-000895	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.2222
p.E329Q	CL-34	large_intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.2222
p.T327I	SIDM00733	Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.T327I	ACH-000525	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1667
p.T327I	NCI-H2171	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.T343R	ACH-001853	Bile Duct Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1667
p.T336K	GAK	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14529	Homeobox protein cut-like 2	DEG_SPOP_SBC_1	1413:1417	VPSSS	SPOP	0.9369	More...
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DEG_SPOP_SBC_1	403:407	VPSSS	SPOP	0.9934	More...
O43379	WD repeat-containing protein 62	DEG_SPOP_SBC_1	1045:1049	VPSSS	SPOP	0.9969	More...
O60238	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	DEG_SPOP_SBC_1	60:64	VPSSS	SPOP	0.9969	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	1466:1470	VPSSS	SPOP	0.9135	More...
O60353	Frizzled-6	DEG_SPOP_SBC_1	671:675	VPSSS	SPOP	0.997	More...
P20823	Hepatocyte nuclear factor 1-alpha	DEG_SPOP_SBC_1	333:337	VPSSS	SPOP	0.9824	More...
Q04756	Hepatocyte growth factor activator	DEG_SPOP_SBC_1	90:94	VPSSS	SPOP	0.9524	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	498:502	VPSSS	SPOP	0.9751	More...
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	36:40	VPSSS	SPOP	0.9447	More...
Q15517	Corneodesmosin	DEG_SPOP_SBC_1	398:402	VPSSS	SPOP	0.9779	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	969:973	VPSSS	SPOP	0.9317	More...
Q33E94	Transcription factor RFX4	DEG_SPOP_SBC_1	580:584	VPSSS	SPOP	0.9636	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	894:898	VPSSS	SPOP	0.9972	More...
Q5JRX3	Presequence protease, mitochondrial	DEG_SPOP_SBC_1	822:826	VPSSS	SPOP	0.8258	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1676:1680	VPSSS	SPOP	0.931	More...
Q6DJT9	Zinc finger protein PLAG1	DEG_SPOP_SBC_1	367:371	VPSSS	SPOP	0.7608	More...
Q6ZU64	Cilia- and flagella-associated protein 65	DEG_SPOP_SBC_1	1733:1737	VPSSS	SPOP	0.9924	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	596:600	VPSSS	SPOP	0.9945	More...
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SPOP_SBC_1	424:428	VPSSS	SPOP	0.9587	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1219:1223	VPSSS	SPOP	0.9215	More...
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	452:456	VPSSS	SPOP	0.9261	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	4002:4006	VPSSS	SPOP	0.603	More...
Q8NI35	InaD-like protein	DEG_SPOP_SBC_1	1335:1339	VPSSS	SPOP	0.9943	More...
Q96CF2	Charged multivesicular body protein 4c	DEG_SPOP_SBC_1	188:192	VPSSS	SPOP	0.9968	More...
Q9H2F5	Enhancer of polycomb homolog 1	DEG_SPOP_SBC_1	802:806	VPSSS	SPOP	0.9538	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1086:1090	VPSSS	SPOP	0.9575	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4894:4898	VPSSS	SPOP	0.9445	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	278:282	VPSSS	SPOP	0.7948	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	938:942	VPSSS	SPOP	0.8217	More...
Q9Y5Q9	General transcription factor 3C polypeptide 3	DEG_SPOP_SBC_1	53:57	VPSSS	SPOP	0.9944	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SPOP_SBC_1	673:677	VPSSS	SPOP	0.98	More...
Q9NX45	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2	DEG_SPOP_SBC_1	334:338	VPSSS	SPOP	0.9176	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	1515:1519	VPSSS	SPOP	0.97	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	373:377	VPSSS	SPOP	0.992	More...
Q3B8N5	Prospero homeobox protein 2	DEG_SPOP_SBC_1	45:49	VPSSS	SPOP	0.9929	More...
Q5JWR5	Protein dopey-1	DEG_SPOP_SBC_1	904:908	VPSSS	SPOP	0.6091	More...
Q6DHV5	Protein CC2D2B	DEG_SPOP_SBC_1	173:177	VPSSS	SPOP	0.9766	More...
Q8N9U0	Tandem C2 domains nuclear protein	DEG_SPOP_SBC_1	195:199	VPSSS	SPOP	0.8511	More...
P0CJ78	Zinc finger protein 865	DEG_SPOP_SBC_1	91:95	VPSSS	SPOP	0.9935	More...
Q8N9C0	Immunoglobulin superfamily member 22	DEG_SPOP_SBC_1	788:792	VPSSS	SPOP	0.9873	More...
Q96MR7	Putative uncharacterized protein OBSCN-AS1	DEG_SPOP_SBC_1	19:23	VPSSS	SPOP	0.7429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSSS

Degron related mutations and impact score

Drug responses associated with HNF1A mutations

All proteins holding degron of VPSSS