DegronMD - Q5JRX3(PITRM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D191N	TCGA-2W-A8YY	CESC	TCGA	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1111
p.N213D	TCGA-EO-A22R	UCEC	TCGA	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1111
p.V833I	TCGA-EO-A22U	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1389
p.L194F	DO481	BLCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation blocking phosphorylation signal	0.6389
p.P195S	DO20778	KIRP	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.2222
p.H831N	DO228952	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1944
p.P815Q	DO228974	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1389
p.H831Q	DO229038	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1944
p.R814C	DO229054	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1111
p.R814C	DO50688	ORCA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1111
p.P812H	DO229006	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.0556
p.D196Y	DO23726	LUAD	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.25
p.T198M	DO50734	ORCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.3056
p.R814H	DO228138	PBCA	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1111
p.E212D	DO232224	PBCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1389
p.S200T	DO229259	THCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation altering degron motif	0.7116
p.V832I	DO43755	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1667
p.V832I	ACH-001786	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1667
p.R815H	SIDM02059	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.1389
p.P192L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1389
p.P192L	ACH-000669	Lung Cancer	CCLE	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1389
p.P192L	SW900	lung	COSMIC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1389
p.D212G	SIDM01450	Gastric Carcinoma	GDSC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1389
p.D212G	ACH-000898	Gastric Cancer	CCLE	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1389
p.D206N	8305C	thyroid	COSMIC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.3056
p.R191W	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	199:205	Mutation rewiring degron network	0.1111
p.S836C	KE-37	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	822:826	Mutation rewiring degron network	0.0556

Kaplan plot for PITRM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITRM1

UniProt ID: Q5JRX3

Entrez ID: 10531

Protein name: Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITRM1 in