DegronMD

Uniprot ID: Q5JRX3

Source protein: Presequence protease, mitochondrial

Source gene: PITRM1

Class: LIG_APCC_ABBAyCdc20_2

Location: 199:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6789

ASA_SCORE: 21.7571

COIL: 0.2773

CONS_SCORE: 0.7478

DSS_SCORE: 0.2974

HELIX: 0.0791

FCONS_SCORE: 1.841

RIG_SCORE: 0.8262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D191N	TCGA-2W-A8YY	CESC	TCGA	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.N213D	TCGA-EO-A22R	UCEC	TCGA	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L194F	DO481	BLCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.6389
p.P195S	DO20778	KIRP	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D196Y	DO23726	LUAD	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.25
p.T198M	DO50734	ORCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E212D	DO232224	PBCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S200T	DO229259	THCA	ICGC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.7116
p.P192L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P192L	ACH-000669	Lung Cancer	CCLE	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P192L	SW900	lung	COSMIC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D212G	SIDM01450	Gastric Carcinoma	GDSC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D212G	ACH-000898	Gastric Cancer	CCLE	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D206N	8305C	thyroid	COSMIC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R191W	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	KGVVFNE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JRX3	Presequence protease, mitochondrial	LIG_APCC_ABBAyCdc20_2	199:205	KGVVFNE	APC,CDC20,FZR1	0.6789	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons