DegronMD - Q15517(CDSN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R397Q	TCGA-A5-A0G2	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.3056
p.R397Q	DO41235	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.3056
p.P511L	TCGA-EE-A2MS	SKCM	TCGA	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.2222
p.P511L	DO23270	LINC	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.2222
p.P511L	DO37567	SKCM	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.2222
p.P393L	TCGA-FW-A3R5	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.P393L	DO220886	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.P393L	DO37406	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.L410S	DO48461	BLCA	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1111
p.L410S	DO231070	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1111
p.S408A	DO229505	LAML	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1667
p.S408A	DO230659	LAML	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1667
p.S408A	DO231049	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1667
p.R500Q	DO231890	LINC	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation altering degron motif	0.7329
p.S405F	DO222413	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.25
p.I494T	DO219881	SKCA	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.1944
p.G409V	SIDM00578	Neuroblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00773	Non-Cancerous	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00234	Other Solid Cancers	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00617	Hepatocellular Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00967	Ovarian Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00319	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00584	Osteosarcoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00781	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00370	T-Lymphoblastic Leukemia	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01005	Acute Myeloid Leukemia	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00267	Biliary Tract Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00296	Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00589	Oral Cavity Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00571	Pancreatic Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00533	Pancreatic Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00529	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00998	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00301	Pancreatic Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00556	Neuroblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00562	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00487	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01265	Plasma Cell Myeloma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01653	Non-Cancerous	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00970	Bladder Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00616	Hepatocellular Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00793	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01217	Other Blood Cancers	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00324	Neuroblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00863	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00363	Acute Myeloid Leukemia	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00554	Ovarian Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00774	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00273	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00575	Glioma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01318	Hepatocellular Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01582	Gastric Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01617	Endometrial Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01335	Kidney Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01498	Acute Myeloid Leukemia	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00169	Head and Neck Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01336	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00166	Other Solid Cancers	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01779	Gastric Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00780	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00161	Biliary Tract Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01446	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00500	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM00171	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01753	Gastric Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409V	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.P393S	SIDM01060	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.P393S	IGR-1	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.G409S	SIDM00140	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409S	ACH-000968	Skin Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.G409S	COLO-792	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1389
p.R497H	SIDM00359	Colorectal Carcinoma	GDSC	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.2778
p.R497H	ACH-000565	Colon/Colorectal Cancer	CCLE	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.2778
p.R497H	RCM-1	large intestine	COSMIC	IRDILAQVK	DEG_APCC_DBOX_1	499:507	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDSN

UniProt ID: Q15517

Entrez ID: 1041

Protein name: Corneodesmosin (S protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDSN in