DegronMD

Uniprot ID: Q15517

Source protein: Corneodesmosin

Source gene: CDSN

Class: DEG_APCC_DBOX_1

Location: 499:507

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5872

ASA_SCORE: 75.8

COIL: 0.4838

CONS_SCORE: 0.9251

DSS_SCORE: 0.3933

HELIX: 0.4659

FCONS_SCORE: 1.1714

RIG_SCORE: 0.805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P511L	TCGA-EE-A2MS	SKCM	TCGA	IRDILAQVK	DEG_APCC_DBOX_1	0.2222
p.P511L	DO23270	LINC	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	0.2222
p.P511L	DO37567	SKCM	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	0.2222
p.R500Q	DO231890	LINC	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	0.7329
p.I494T	DO219881	SKCA	ICGC	IRDILAQVK	DEG_APCC_DBOX_1	0.1944
p.R497H	SIDM00359	Colorectal Carcinoma	GDSC	IRDILAQVK	DEG_APCC_DBOX_1	0.2778
p.R497H	ACH-000565	Colon/Colorectal Cancer	CCLE	IRDILAQVK	DEG_APCC_DBOX_1	0.2778
p.R497H	RCM-1	large_intestine	COSMIC	IRDILAQVK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15517	Corneodesmosin	DEG_APCC_DBOX_1	499:507	IRDILAQVK	APC,CDC20,FZR1	0.5872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons