DegronMD - Q8N9U0(TC2N)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S199C	TCGA-A8-A06Y	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.7541
p.S199C	DO4872	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.7541
p.S199T	TCGA-A8-A06Y	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.6005
p.S199T	DO4872	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.6005
p.R202K	TCGA-D3-A8GI	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.25
p.R202K	DO50284	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.25
p.N204S	TCGA-EE-A2GC	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1944
p.N204S	DO37839	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1944
p.P196L	TCGA-FS-A4F5	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.6471
p.P196L	DO37881	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.6471
p.D190H	DO234354	ESAD	ICGC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1944
p.S193P	SIDM00082	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2778
p.S193P	ACH-001190	Skin Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2778
p.S193P	SK-MEL-2	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2778
p.S205F	SIDM01175	Other Sarcomas	GDSC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation blocking phosphorylation signal	0.6111
p.S205F	ACH-002309	Sarcoma	CCLE	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation blocking phosphorylation signal	0.6111
p.S205F	SW684	soft tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation blocking phosphorylation signal	0.6111
p.Q206H	ACH-000918	Leukemia	CCLE	VPSSS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1389

Kaplan plot for TC2N in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TC2N

UniProt ID: Q8N9U0

Entrez ID: 123036

Protein name: Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TC2N in