DegronMD

Uniprot ID: Q8N9U0

Source protein: Tandem C2 domains nuclear protein

Source gene: TC2N

Class: DEG_SPOP_SBC_1

Location: 195:199

E3 ligase: SPOP

DEGRON score: 0.8511

ASA_SCORE: 73.1

COIL: 0.8878

CONS_SCORE: 0.8097

DSS_SCORE: 0.6627

HELIX: 0.0592

FCONS_SCORE: 0.9949

RIG_SCORE: 0.5546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S199C	TCGA-A8-A06Y	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	0.7541
p.S199C	DO4872	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.7541
p.S199T	TCGA-A8-A06Y	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	0.6005
p.S199T	DO4872	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.6005
p.R202K	TCGA-D3-A8GI	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.25
p.R202K	DO50284	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.25
p.N204S	TCGA-EE-A2GC	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1944
p.N204S	DO37839	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.P196L	TCGA-FS-A4F5	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.6471
p.P196L	DO37881	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.6471
p.D190H	DO234354	ESAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.S193P	SIDM00082	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.2778
p.S193P	ACH-001190	Skin Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.2778
p.S193P	SK-MEL-2	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.2778
p.S205F	SIDM01175	Other Sarcomas	GDSC	VPSSS	DEG_SPOP_SBC_1	0.6111
p.S205F	ACH-002309	Sarcoma	CCLE	VPSSS	DEG_SPOP_SBC_1	0.6111
p.S205F	SW684	soft_tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.6111
p.Q206H	ACH-000918	Leukemia	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14529	Homeobox protein cut-like 2	DEG_SPOP_SBC_1	1413:1417	VPSSS	SPOP	0.9369	More...
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DEG_SPOP_SBC_1	403:407	VPSSS	SPOP	0.9934	More...
O43379	WD repeat-containing protein 62	DEG_SPOP_SBC_1	1045:1049	VPSSS	SPOP	0.9969	More...
O60238	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	DEG_SPOP_SBC_1	60:64	VPSSS	SPOP	0.9969	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	1466:1470	VPSSS	SPOP	0.9135	More...
O60353	Frizzled-6	DEG_SPOP_SBC_1	671:675	VPSSS	SPOP	0.997	More...
P20823	Hepatocyte nuclear factor 1-alpha	DEG_SPOP_SBC_1	333:337	VPSSS	SPOP	0.9824	More...
Q04756	Hepatocyte growth factor activator	DEG_SPOP_SBC_1	90:94	VPSSS	SPOP	0.9524	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	498:502	VPSSS	SPOP	0.9751	More...
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	36:40	VPSSS	SPOP	0.9447	More...
Q15517	Corneodesmosin	DEG_SPOP_SBC_1	398:402	VPSSS	SPOP	0.9779	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	969:973	VPSSS	SPOP	0.9317	More...
Q33E94	Transcription factor RFX4	DEG_SPOP_SBC_1	580:584	VPSSS	SPOP	0.9636	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	894:898	VPSSS	SPOP	0.9972	More...
Q5JRX3	Presequence protease, mitochondrial	DEG_SPOP_SBC_1	822:826	VPSSS	SPOP	0.8258	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1676:1680	VPSSS	SPOP	0.931	More...
Q6DJT9	Zinc finger protein PLAG1	DEG_SPOP_SBC_1	367:371	VPSSS	SPOP	0.7608	More...
Q6ZU64	Cilia- and flagella-associated protein 65	DEG_SPOP_SBC_1	1733:1737	VPSSS	SPOP	0.9924	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	596:600	VPSSS	SPOP	0.9945	More...
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SPOP_SBC_1	424:428	VPSSS	SPOP	0.9587	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1219:1223	VPSSS	SPOP	0.9215	More...
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	452:456	VPSSS	SPOP	0.9261	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	4002:4006	VPSSS	SPOP	0.603	More...
Q8NI35	InaD-like protein	DEG_SPOP_SBC_1	1335:1339	VPSSS	SPOP	0.9943	More...
Q96CF2	Charged multivesicular body protein 4c	DEG_SPOP_SBC_1	188:192	VPSSS	SPOP	0.9968	More...
Q9H2F5	Enhancer of polycomb homolog 1	DEG_SPOP_SBC_1	802:806	VPSSS	SPOP	0.9538	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1086:1090	VPSSS	SPOP	0.9575	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4894:4898	VPSSS	SPOP	0.9445	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	278:282	VPSSS	SPOP	0.7948	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	938:942	VPSSS	SPOP	0.8217	More...
Q9Y5Q9	General transcription factor 3C polypeptide 3	DEG_SPOP_SBC_1	53:57	VPSSS	SPOP	0.9944	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SPOP_SBC_1	673:677	VPSSS	SPOP	0.98	More...
Q9NX45	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2	DEG_SPOP_SBC_1	334:338	VPSSS	SPOP	0.9176	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	1515:1519	VPSSS	SPOP	0.97	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	373:377	VPSSS	SPOP	0.992	More...
Q3B8N5	Prospero homeobox protein 2	DEG_SPOP_SBC_1	45:49	VPSSS	SPOP	0.9929	More...
Q5JWR5	Protein dopey-1	DEG_SPOP_SBC_1	904:908	VPSSS	SPOP	0.6091	More...
Q6DHV5	Protein CC2D2B	DEG_SPOP_SBC_1	173:177	VPSSS	SPOP	0.9766	More...
Q8N9U0	Tandem C2 domains nuclear protein	DEG_SPOP_SBC_1	195:199	VPSSS	SPOP	0.8511	More...
P0CJ78	Zinc finger protein 865	DEG_SPOP_SBC_1	91:95	VPSSS	SPOP	0.9935	More...
Q8N9C0	Immunoglobulin superfamily member 22	DEG_SPOP_SBC_1	788:792	VPSSS	SPOP	0.9873	More...
Q96MR7	Putative uncharacterized protein OBSCN-AS1	DEG_SPOP_SBC_1	19:23	VPSSS	SPOP	0.7429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSSS

Degron related mutations and impact score

Drug responses associated with TC2N mutations

All proteins holding degron of VPSSS