DegronMD - Q96CF2(CHMP4C)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R63Q	TCGA-06-5416	GBM	TCGA	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7329
p.R63Q	DO10880	GBM	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7329
p.R63Q	DO222423	MELA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7329
p.R63Q	DO37425	SKCM	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.7329
p.P194L	TCGA-14-1458	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2778
p.P194L	DO13851	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2778
p.R184H	TCGA-77-7142	LUSC	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184H	TCGA-A5-A0G2	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184H	DO233272	GACA	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184H	DO26462	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184H	DO41235	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.K179N	TCGA-AG-A002	READ	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation substituting flanking lysine	0.1944
p.R184C	TCGA-B5-A11E	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184C	TCGA-D8-A1JM	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184C	DO2497	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.R184C	DO41644	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2222
p.Q78H	TCGA-DX-A6YS	SARC	TCGA	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1111
p.Q78H	DO220005	SARC	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1111
p.N182D	TCGA-E6-A1LX	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.1667
p.N182D	DO41020	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.1667
p.R71I	DO222884	COCA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.3056
p.A68S	DO229036	LICA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6477
p.S191C	DO230968	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.7541
p.S191C	DO224621	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.7541
p.E76G	DO229268	THCA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.P186S	SIDM01175	Other Sarcomas	GDSC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2778
p.P186S	ACH-002309	Sarcoma	CCLE	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2778
p.P186S	SW684	soft tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.2778
p.E76K	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.E76K	ACH-000488	Esophageal Cancer	CCLE	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.E76K	TE-11	oesophagus	COSMIC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1667
p.H57Q	ACH-001802	Liposarcoma	CCLE	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1944

Kaplan plot for CHMP4C in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHMP4C

UniProt ID: Q96CF2

Entrez ID: 92421

Protein name: Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CHMP4C in