DegronMD

Uniprot ID: Q96CF2

Source protein: Charged multivesicular body protein 4c

Source gene: CHMP4C

Class: DEG_APCC_DBOX_1

Location: 62:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5731

ASA_SCORE: 96.9222

COIL: 0.0898

CONS_SCORE: 0.694

DSS_SCORE: 0.4923

HELIX: 0.9121

FCONS_SCORE: 1.1523

RIG_SCORE: 0.7932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63Q	TCGA-06-5416	GBM	TCGA	KRAALQALK	DEG_APCC_DBOX_1	0.7329
p.R63Q	DO10880	GBM	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.7329
p.R63Q	DO222423	MELA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.7329
p.R63Q	DO37425	SKCM	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.7329
p.Q78H	TCGA-DX-A6YS	SARC	TCGA	KRAALQALK	DEG_APCC_DBOX_1	0.1111
p.Q78H	DO220005	SARC	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.1111
p.R71I	DO222884	COCA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.3056
p.A68S	DO229036	LICA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.6477
p.E76G	DO229268	THCA	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.1667
p.E76K	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	KRAALQALK	DEG_APCC_DBOX_1	0.1667
p.E76K	ACH-000488	Esophageal Cancer	CCLE	KRAALQALK	DEG_APCC_DBOX_1	0.1667
p.E76K	TE-11	oesophagus	COSMIC	KRAALQALK	DEG_APCC_DBOX_1	0.1667
p.H57Q	ACH-001802	Liposarcoma	CCLE	KRAALQALK	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CF2	Charged multivesicular body protein 4c	DEG_APCC_DBOX_1	62:70	KRAALQALK	APC,CDC20,FZR1	0.5731	More...
Q9H444	Charged multivesicular body protein 4b	DEG_APCC_DBOX_1	62:70	KRAALQALK	APC,CDC20,FZR1	0.8257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons