DegronMD - Q9H444(CHMP4B)

FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R71S	TCGA-24-0980	OV	TCGA	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.3056
p.R71S	DO32487	OV	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.3056
p.A68T	TCGA-2W-A8YY	CESC	TCGA	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6028
p.A68T	DO223732	CESC	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation altering degron motif	0.6028
p.Y75H	TCGA-67-3771	LUAD	TCGA	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1944
p.Y75H	DO25797	LUAD	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.1944
p.R71C	TCGA-EC-A24G	UCEC	TCGA	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.3056
p.R71C	DO40996	UCEC	ICGC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.3056
p.T59I	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25
p.T59I	ACH-002393	Lymphoma	CCLE	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25
p.T59I	CRO-AP3	NS	COSMIC	KRAALQALK	DEG_APCC_DBOX_1	62:70	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHMP4B

UniProt ID: Q9H444

Entrez ID: 128866

Protein name: Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHMP4B in