DegronMD

Uniprot ID: Q9H444

Source protein: Charged multivesicular body protein 4b

Source gene: CHMP4B

Class: DEG_APCC_DBOX_1

Location: 62:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8257

ASA_SCORE: 89.4889

COIL: 0.0302

CONS_SCORE: 0.709

DSS_SCORE: 0.512

HELIX: 0.9702

FCONS_SCORE: 1.1822

RIG_SCORE: 0.7918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R71S	TCGA-24-0980	OV	TCGA	KRAALQALK	DEG_APCC_DBOX_1	0.3056
p.R71S	DO32487	OV	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.3056
p.A68T	TCGA-2W-A8YY	CESC	TCGA	KRAALQALK	DEG_APCC_DBOX_1	0.6028
p.A68T	DO223732	CESC	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.6028
p.Y75H	TCGA-67-3771	LUAD	TCGA	KRAALQALK	DEG_APCC_DBOX_1	0.1944
p.Y75H	DO25797	LUAD	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.1944
p.R71C	TCGA-EC-A24G	UCEC	TCGA	KRAALQALK	DEG_APCC_DBOX_1	0.3056
p.R71C	DO40996	UCEC	ICGC	KRAALQALK	DEG_APCC_DBOX_1	0.3056
p.T59I	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRAALQALK	DEG_APCC_DBOX_1	0.25
p.T59I	ACH-002393	Lymphoma	CCLE	KRAALQALK	DEG_APCC_DBOX_1	0.25
p.T59I	CRO-AP3	NS	COSMIC	KRAALQALK	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CF2	Charged multivesicular body protein 4c	DEG_APCC_DBOX_1	62:70	KRAALQALK	APC,CDC20,FZR1	0.5731	More...
Q9H444	Charged multivesicular body protein 4b	DEG_APCC_DBOX_1	62:70	KRAALQALK	APC,CDC20,FZR1	0.8257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons