DegronMD

Uniprot ID: O14529

Source protein: Homeobox protein cut-like 2

Source gene: CUX2

Class: DEG_SPOP_SBC_1

Location: 1413:1417

E3 ligase: SPOP

DEGRON score: 0.9369

ASA_SCORE: 84.88

COIL: 0.9556

CONS_SCORE: 0.3224

DSS_SCORE: 0.5278

HELIX: 0.03

FCONS_SCORE: 0.9553

RIG_SCORE: 0.5358

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1412H	TCGA-A5-A0G1	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.3056
p.P1412H	DO42472	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.3056
p.V1410E	TCGA-AA-3966	COAD	TCGA	VPSSS	DEG_SPOP_SBC_1	0.25
p.V1410E	DO10068	COAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.25
p.S1409Y	TCGA-DU-6392	LGG	TCGA	VPSSS	DEG_SPOP_SBC_1	0.2222
p.S1409Y	DO22237	LGG	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2222
p.S1421F	TCGA-EE-A3JA	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.2222
p.S1421F	DO47625	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2222
p.M1408I	TCGA-CG-5732	STAD	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1944
p.M1408I	DO38471	STAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.S1423F	TCGA-EB-A430	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1667
p.S1423F	DO37906	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.P1424S	TCGA-W3-A825	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1389
p.P1424S	DO51272	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1389
p.P1424T	DO229053	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1389
p.P1404T	DO224563	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A1427T	TCGA-EE-A2MM	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.0556
p.A1427T	DO222678	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0556
p.A1427T	DO37770	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0556
p.A1427S	DO229009	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 20 of 20 entries

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Drug responses associated with CUX2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VPSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1219:1223	VPSSS	SPOP	0.9215	More...
O60238	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	DEG_SPOP_SBC_1	60:64	VPSSS	SPOP	0.9969	More...
Q96CF2	Charged multivesicular body protein 4c	DEG_SPOP_SBC_1	188:192	VPSSS	SPOP	0.9968	More...
Q6ZU64	Cilia- and flagella-associated protein 65	DEG_SPOP_SBC_1	1733:1737	VPSSS	SPOP	0.9924	More...
Q15517	Corneodesmosin	DEG_SPOP_SBC_1	398:402	VPSSS	SPOP	0.9779	More...
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DEG_SPOP_SBC_1	403:407	VPSSS	SPOP	0.9934	More...
Q9H2F5	Enhancer of polycomb homolog 1	DEG_SPOP_SBC_1	802:806	VPSSS	SPOP	0.9538	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	894:898	VPSSS	SPOP	0.9972	More...
O60353	Frizzled-6	DEG_SPOP_SBC_1	671:675	VPSSS	SPOP	0.997	More...
Q9Y5Q9	General transcription factor 3C polypeptide 3	DEG_SPOP_SBC_1	53:57	VPSSS	SPOP	0.9944	More...
Q04756	Hepatocyte growth factor activator	DEG_SPOP_SBC_1	90:94	VPSSS	SPOP	0.9524	More...
P20823	Hepatocyte nuclear factor 1-alpha	DEG_SPOP_SBC_1	333:337	VPSSS	SPOP	0.9824	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	4002:4006	VPSSS	SPOP	0.603	More...
O14529	Homeobox protein cut-like 2	DEG_SPOP_SBC_1	1413:1417	VPSSS	SPOP	0.9369	More...
Q8N9C0	Immunoglobulin superfamily member 22	DEG_SPOP_SBC_1	788:792	VPSSS	SPOP	0.9873	More...
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SPOP_SBC_1	424:428	VPSSS	SPOP	0.9587	More...
Q8NI35	InaD-like protein	DEG_SPOP_SBC_1	1335:1339	VPSSS	SPOP	0.9943	More...
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	36:40	VPSSS	SPOP	0.9447	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4894:4898	VPSSS	SPOP	0.9445	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	1466:1470	VPSSS	SPOP	0.9135	More...
Q5JRX3	Presequence protease, mitochondrial	DEG_SPOP_SBC_1	822:826	VPSSS	SPOP	0.8258	More...
Q3B8N5	Prospero homeobox protein 2	DEG_SPOP_SBC_1	45:49	VPSSS	SPOP	0.9929	More...
Q6DHV5	Protein CC2D2B	DEG_SPOP_SBC_1	173:177	VPSSS	SPOP	0.9766	More...
Q5JWR5	Protein dopey-1	DEG_SPOP_SBC_1	904:908	VPSSS	SPOP	0.6091	More...
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	452:456	VPSSS	SPOP	0.9261	More...

Showing 1 to 25 of 42 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSSS

Degron related mutations and impact score

Drug responses associated with CUX2 mutations

All proteins holding degron of VPSSS