DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4894:4898

E3 ligase: SPOP

DEGRON score: 0.9445

ASA_SCORE: 85.04

COIL: 0.941

CONS_SCORE: 0.2699

DSS_SCORE: 0.5421

HELIX: 0.0138

FCONS_SCORE: 1.0506

RIG_SCORE: 0.6783

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4904H	TCGA-06-0219	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	TCGA-55-A4DG	LUAD	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	TCGA-EO-A22X	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	SIDM00963	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	SIDM00382	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	SIDM01609	Endometrial Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	SIDM01608	Endometrial Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	ACH-000609	Brain Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	ACH-000914	Lymphoma	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R4904H	ACH-000927	Breast Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1667
p.V4900M	TCGA-3M-AB47	STAD	TCGA	VPSSS	DEG_SPOP_SBC_1	0.2778
p.V4900M	TCGA-DU-6392	LGG	TCGA	VPSSS	DEG_SPOP_SBC_1	0.2778
p.T4893M	TCGA-69-7763	LUAD	TCGA	VPSSS	DEG_SPOP_SBC_1	0.3056
p.T4893M	SIDM00282	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.3056
p.T4893M	SIDM00327	Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.3056
p.R4904P	TCGA-CN-A63W	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1667
p.V4908L	TCGA-EO-A22R	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	0.0556
p.P4890L	DO234389	ESAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2222
p.P4890L	DO220908	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2222
p.S4899I	DO234285	ESAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.3056
p.R4907H	DO12928	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.R4907H	DO26337	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.R4907H	DO231495	THCA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.R4907H	DO43907	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.R4907P	DO49031	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.T4885A	DO231140	LAML	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.T4885A	DO229047	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.T4885A	DO231067	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.V4903M	DO22237	LGG	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.V4903M	DO222327	STAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.A4892S	DO228986	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2778
p.T4896M	DO24616	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.7423
p.R4907C	DO231075	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A4907S	SIDM01218	Other Solid Cancers	GDSC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A4907S	ACH-001530	Endometrial/Uterine Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A4907S	JEG-3	placenta	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A4889D	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.A4889D	ACH-000282	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1944
p.A4889D	NCI-H1755	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	0.1944
p.A4907V	SIDM01608	Endometrial Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.A4907V	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.0833
p.M4886I	ACH-000975	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14529	Homeobox protein cut-like 2	DEG_SPOP_SBC_1	1413:1417	VPSSS	SPOP	0.9369	More...
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DEG_SPOP_SBC_1	403:407	VPSSS	SPOP	0.9934	More...
O43379	WD repeat-containing protein 62	DEG_SPOP_SBC_1	1045:1049	VPSSS	SPOP	0.9969	More...
O60238	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	DEG_SPOP_SBC_1	60:64	VPSSS	SPOP	0.9969	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	1466:1470	VPSSS	SPOP	0.9135	More...
O60353	Frizzled-6	DEG_SPOP_SBC_1	671:675	VPSSS	SPOP	0.997	More...
P20823	Hepatocyte nuclear factor 1-alpha	DEG_SPOP_SBC_1	333:337	VPSSS	SPOP	0.9824	More...
Q04756	Hepatocyte growth factor activator	DEG_SPOP_SBC_1	90:94	VPSSS	SPOP	0.9524	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	498:502	VPSSS	SPOP	0.9751	More...
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	36:40	VPSSS	SPOP	0.9447	More...
Q15517	Corneodesmosin	DEG_SPOP_SBC_1	398:402	VPSSS	SPOP	0.9779	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	969:973	VPSSS	SPOP	0.9317	More...
Q33E94	Transcription factor RFX4	DEG_SPOP_SBC_1	580:584	VPSSS	SPOP	0.9636	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	894:898	VPSSS	SPOP	0.9972	More...
Q5JRX3	Presequence protease, mitochondrial	DEG_SPOP_SBC_1	822:826	VPSSS	SPOP	0.8258	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1676:1680	VPSSS	SPOP	0.931	More...
Q6DJT9	Zinc finger protein PLAG1	DEG_SPOP_SBC_1	367:371	VPSSS	SPOP	0.7608	More...
Q6ZU64	Cilia- and flagella-associated protein 65	DEG_SPOP_SBC_1	1733:1737	VPSSS	SPOP	0.9924	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	596:600	VPSSS	SPOP	0.9945	More...
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SPOP_SBC_1	424:428	VPSSS	SPOP	0.9587	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1219:1223	VPSSS	SPOP	0.9215	More...
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	452:456	VPSSS	SPOP	0.9261	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	4002:4006	VPSSS	SPOP	0.603	More...
Q8NI35	InaD-like protein	DEG_SPOP_SBC_1	1335:1339	VPSSS	SPOP	0.9943	More...
Q96CF2	Charged multivesicular body protein 4c	DEG_SPOP_SBC_1	188:192	VPSSS	SPOP	0.9968	More...
Q9H2F5	Enhancer of polycomb homolog 1	DEG_SPOP_SBC_1	802:806	VPSSS	SPOP	0.9538	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1086:1090	VPSSS	SPOP	0.9575	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4894:4898	VPSSS	SPOP	0.9445	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	278:282	VPSSS	SPOP	0.7948	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	938:942	VPSSS	SPOP	0.8217	More...
Q9Y5Q9	General transcription factor 3C polypeptide 3	DEG_SPOP_SBC_1	53:57	VPSSS	SPOP	0.9944	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SPOP_SBC_1	673:677	VPSSS	SPOP	0.98	More...
Q9NX45	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2	DEG_SPOP_SBC_1	334:338	VPSSS	SPOP	0.9176	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	1515:1519	VPSSS	SPOP	0.97	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	373:377	VPSSS	SPOP	0.992	More...
Q3B8N5	Prospero homeobox protein 2	DEG_SPOP_SBC_1	45:49	VPSSS	SPOP	0.9929	More...
Q5JWR5	Protein dopey-1	DEG_SPOP_SBC_1	904:908	VPSSS	SPOP	0.6091	More...
Q6DHV5	Protein CC2D2B	DEG_SPOP_SBC_1	173:177	VPSSS	SPOP	0.9766	More...
Q8N9U0	Tandem C2 domains nuclear protein	DEG_SPOP_SBC_1	195:199	VPSSS	SPOP	0.8511	More...
P0CJ78	Zinc finger protein 865	DEG_SPOP_SBC_1	91:95	VPSSS	SPOP	0.9935	More...
Q8N9C0	Immunoglobulin superfamily member 22	DEG_SPOP_SBC_1	788:792	VPSSS	SPOP	0.9873	More...
Q96MR7	Putative uncharacterized protein OBSCN-AS1	DEG_SPOP_SBC_1	19:23	VPSSS	SPOP	0.7429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSSS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VPSSS