DegronMD - O43237(DYNC1LI2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V59I	TCGA-2W-A8YY	CESC	TCGA	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.5965
p.V59I	DO223732	CESC	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.5965
p.R48M	TCGA-3B-A9HL	SARC	TCGA	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.0833
p.R48M	DO219928	SARC	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.0833
p.R393M	TCGA-A5-A0G2	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.0556
p.R393M	DO41235	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.0556
p.R397W	TCGA-B5-A11Y	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1667
p.R397W	DO40889	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1667
p.D63H	TCGA-D8-A1JK	BRCA	TCGA	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.3056
p.D63H	DO3880	BRCA	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.3056
p.S49F	TCGA-EE-A3J5	SKCM	TCGA	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.S49F	DO47331	SKCM	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.G61C	TCGA-HE-7129	KIRP	TCGA	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.6489
p.G61C	DO20786	KIRP	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.6489
p.L70I	TCGA-HU-A4GQ	STAD	TCGA	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.L70I	DO47767	STAD	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.P404T	DO229009	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation altering degron motif	0.5919
p.R48S	DO50725	ORCA	ICGC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.0833
p.P415L	SIDM00216	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1111
p.P415L	ACH-000989	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1111
p.P415L	SNU-175	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1111
p.V412I	SIDM00215	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1944
p.V412I	SNU-283	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1944
p.L70M	ACH-000997	Colon/Colorectal Cancer	CCLE	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.L70M	ACH-001061	Colon/Colorectal Cancer	CCLE	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.L70M	HCT-15	large intestine	COSMIC	ILVFGE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111

Kaplan plot for DYNC1LI2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DYNC1LI2

UniProt ID: O43237

Entrez ID: 1783

Protein name: Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DYNC1LI2 in