DegronMD

Uniprot ID: O43237

Source protein: Cytoplasmic dynein 1 light intermediate chain 2

Source gene: DYNC1LI2

Class: LIG_APCC_ABBA_1

Location: 57:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7105

ASA_SCORE: 30.3333

COIL: 0.3797

CONS_SCORE: 0.5964

DSS_SCORE: 0.4168

HELIX: 0.0172

FCONS_SCORE: 1.3043

RIG_SCORE: 0.766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V59I	TCGA-2W-A8YY	CESC	TCGA	ILVFGE	LIG_APCC_ABBA_1	0.5965
p.V59I	DO223732	CESC	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.5965
p.R48M	TCGA-3B-A9HL	SARC	TCGA	ILVFGE	LIG_APCC_ABBA_1	0.0833
p.R48M	DO219928	SARC	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.0833
p.D63H	TCGA-D8-A1JK	BRCA	TCGA	ILVFGE	LIG_APCC_ABBA_1	0.3056
p.D63H	DO3880	BRCA	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.3056
p.S49F	TCGA-EE-A3J5	SKCM	TCGA	ILVFGE	LIG_APCC_ABBA_1	0.1111
p.S49F	DO47331	SKCM	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.1111
p.G61C	TCGA-HE-7129	KIRP	TCGA	ILVFGE	LIG_APCC_ABBA_1	0.6489
p.G61C	DO20786	KIRP	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.6489
p.L70I	TCGA-HU-A4GQ	STAD	TCGA	ILVFGE	LIG_APCC_ABBA_1	0.1111
p.L70I	DO47767	STAD	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.1111
p.R48S	DO50725	ORCA	ICGC	ILVFGE	LIG_APCC_ABBA_1	0.0833
p.L70M	ACH-000997	Colon/Colorectal Cancer	CCLE	ILVFGE	LIG_APCC_ABBA_1	0.1111
p.L70M	ACH-001061	Colon/Colorectal Cancer	CCLE	ILVFGE	LIG_APCC_ABBA_1	0.1111
p.L70M	HCT-15	large_intestine	COSMIC	ILVFGE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43237	Cytoplasmic dynein 1 light intermediate chain 2	LIG_APCC_ABBA_1	57:62	ILVFGE	APC,CDC20,FZR1	0.7105	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons