DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DTYSGPP
Uniprot ID:
P20823
Source protein:
Hepatocyte nuclear factor 1-alpha
Source gene:
HNF1A
Class:
CBL_PTK
Location:
284:290
E3 ligase:
CBL
DEGRON score:
0.6858
ASA_SCORE:
95.6
COIL:
0.8697
CONS_SCORE:
0.5969
DSS_SCORE:
0.604
HELIX:
0.1193
FCONS_SCORE:
0.9448
RIG_SCORE:
0.5653
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R278Q
TCGA-A6-5665
COAD
TCGA
DTYSGPP
CBL_PTK
0.1667
p.R278Q
DO9756
COAD
ICGC
DTYSGPP
CBL_PTK
0.1667
p.P289A
TCGA-AJ-A2QO
UCEC
TCGA
DTYSGPP
CBL_PTK
0.6392
p.P289A
DO42177
UCEC
ICGC
DTYSGPP
CBL_PTK
0.6392
p.R278W
TCGA-AX-A3FT
UCEC
TCGA
DTYSGPP
CBL_PTK
0.1667
p.R278W
DO40801
UCEC
ICGC
DTYSGPP
CBL_PTK
0.1667
p.G292E
TCGA-EE-A2MS
SKCM
TCGA
DTYSGPP
CBL_PTK
0.2778
p.G292E
DO37567
SKCM
ICGC
DTYSGPP
CBL_PTK
0.2778
p.A282T
TCGA-NC-A5HG
LUSC
TCGA
DTYSGPP
CBL_PTK
0.2778
p.A282T
DO45448
LUSC
ICGC
DTYSGPP
CBL_PTK
0.2778
p.T285M
DO224811
BRCA
ICGC
DTYSGPP
CBL_PTK
0.6312
p.T285M
DO33800
PACA
ICGC
DTYSGPP
CBL_PTK
0.6312
p.T285M
ACH-001228
CCLE
DTYSGPP
CBL_PTK
0.6312
p.M283I
DO229015
LICA
ICGC
DTYSGPP
CBL_PTK
0.3056
p.M283I
DO229027
LICA
ICGC
DTYSGPP
CBL_PTK
0.3056
p.G294V
DO229041
LICA
ICGC
DTYSGPP
CBL_PTK
0.2222
p.E274K
DO229456
SKCA
ICGC
DTYSGPP
CBL_PTK
0.0556
p.G288V
SIDM00220
Ovarian Carcinoma
GDSC
DTYSGPP
CBL_PTK
0.6421
p.P291S
SIDM00861
Ovarian Carcinoma
GDSC
DTYSGPP
CBL_PTK
0.3056
p.P289L
SIDM01387
Small Cell Lung Carcinoma
GDSC
DTYSGPP
CBL_PTK
0.6471
p.P289L
ACH-000921
Lung Cancer
CCLE
DTYSGPP
CBL_PTK
0.6471
p.G296V
ACH-001111
Lymphoma
CCLE
DTYSGPP
CBL_PTK
0.1667
p.G296E
ACH-001864
Bile Duct Cancer
CCLE
DTYSGPP
CBL_PTK
0.1667
p.Q284R
NCI-H2066
lung
COSMIC
DTYSGPP
CBL_PTK
0.7329
Drug responses associated with HNF1A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTYSGPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P20823
Hepatocyte nuclear factor 1-alpha
CBL_PTK
284:290
DTYSGPP
CBL
0.6858
More...