DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
NTDPYSQPP
Uniprot ID:
Q8NEZ4
Source protein:
Histone-lysine N-methyltransferase 2C
Source gene:
KMT2C
Class:
CBL_PTK
Location:
2155:2163
E3 ligase:
CBL
DEGRON score:
0.9495
ASA_SCORE:
100.6889
COIL:
0.9724
CONS_SCORE:
0.3648
DSS_SCORE:
0.8511
HELIX:
0.0143
FCONS_SCORE:
1.1363
RIG_SCORE:
0.5304
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S2160F
TCGA-A5-A0G2
UCEC
TCGA
NTDPYSQPP
CBL_PTK
0.7982
p.S2160F
DO41235
UCEC
ICGC
NTDPYSQPP
CBL_PTK
0.7982
p.S2146Y
TCGA-AP-A0LM
UCEC
TCGA
NTDPYSQPP
CBL_PTK
0.0833
p.S2146Y
DO43306
UCEC
ICGC
NTDPYSQPP
CBL_PTK
0.0833
p.P2163H
TCGA-B0-4945
KIRC
TCGA
NTDPYSQPP
CBL_PTK
0.7694
p.P2163H
DO18144
KIRC
ICGC
NTDPYSQPP
CBL_PTK
0.7694
p.T2170I
TCGA-DU-6392
LGG
TCGA
NTDPYSQPP
CBL_PTK
0.1389
p.T2170I
DO22237
LGG
ICGC
NTDPYSQPP
CBL_PTK
0.1389
p.Y2145C
DO27779
MALY
ICGC
NTDPYSQPP
CBL_PTK
0.0556
Drug responses associated with KMT2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NTDPYSQPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEZ4
Histone-lysine N-methyltransferase 2C
CBL_PTK
2155:2163
NTDPYSQPP
CBL
0.9495
More...
