DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SCF_FBW7_1

Location: 2162:2169

E3 ligase: FBXW7

DEGRON score: 0.8664

ASA_SCORE: 94.0875

COIL: 0.9733

CONS_SCORE: 0.3513

DSS_SCORE: 0.8504

HELIX: 0.0098

FCONS_SCORE: 1.004

RIG_SCORE: 0.5285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2163H	TCGA-B0-4945	KIRC	TCGA	PPGTPRPT	DEG_SCF_FBW7_1	0.6583
p.P2163H	DO18144	KIRC	ICGC	PPGTPRPT	DEG_SCF_FBW7_1	0.6583
p.T2170I	TCGA-DU-6392	LGG	TCGA	PPGTPRPT	DEG_SCF_FBW7_1	0.3056
p.T2170I	DO22237	LGG	ICGC	PPGTPRPT	DEG_SCF_FBW7_1	0.3056
p.P2166S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PPGTPRPT	DEG_SCF_FBW7_1	0.6752
p.P2166S	ACH-002211	Leukemia	CCLE	PPGTPRPT	DEG_SCF_FBW7_1	0.6752
p.P2166S	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPRPT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	2162:2169	PPGTPRPT	FBXW7	0.8664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons