DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DPYSQQP
Uniprot ID:
Q8NEZ4
Source protein:
Histone-lysine N-methyltransferase 2C
Source gene:
KMT2C
Class:
CBL_PTK
Location:
2172:2178
E3 ligase:
CBL
DEGRON score:
0.8415
ASA_SCORE:
101.3571
COIL:
0.9586
CONS_SCORE:
0.3733
DSS_SCORE:
0.8835
HELIX:
0.0299
FCONS_SCORE:
1.0468
RIG_SCORE:
0.6194
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D2172G
TCGA-BR-4184
STAD
TCGA
DPYSQQP
CBL_PTK
0.7198
p.D2172G
DO38328
STAD
ICGC
DPYSQQP
CBL_PTK
0.7198
p.T2170I
TCGA-DU-6392
LGG
TCGA
DPYSQQP
CBL_PTK
0.2778
p.T2170I
DO22237
LGG
ICGC
DPYSQQP
CBL_PTK
0.2778
p.S2175G
TCGA-V9-A7HT
KIRP
TCGA
DPYSQQP
CBL_PTK
0.6993
p.S2175G
DO219717
KIRP
ICGC
DPYSQQP
CBL_PTK
0.6993
Drug responses associated with KMT2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPYSQQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEZ4
Histone-lysine N-methyltransferase 2C
CBL_PTK
2172:2178
DPYSQQP
CBL
0.8415
More...
