DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DPYSQPP
Uniprot ID:
Q8NEZ4
Source protein:
Histone-lysine N-methyltransferase 2C
Source gene:
KMT2C
Class:
CBL_PTK
Location:
2129:2135
E3 ligase:
CBL
DEGRON score:
0.9833
ASA_SCORE:
100.1857
COIL:
0.9716
CONS_SCORE:
0.3904
DSS_SCORE:
0.8311
HELIX:
0.0186
FCONS_SCORE:
1.1003
RIG_SCORE:
0.5534
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G2136V
TCGA-2W-A8YY
CESC
TCGA
DPYSQPP
CBL_PTK
0.3056
p.G2136V
DO223732
CESC
ICGC
DPYSQPP
CBL_PTK
0.3056
p.R2139Q
TCGA-A6-6781
COAD
TCGA
DPYSQPP
CBL_PTK
0.2222
p.R2139Q
DO8447
COAD
ICGC
DPYSQPP
CBL_PTK
0.2222
p.R2139Q
SIDM01588
Endometrial Carcinoma
GDSC
DPYSQPP
CBL_PTK
0.2222
p.R2139Q
ACH-000993
Endometrial/Uterine Cancer
CCLE
DPYSQPP
CBL_PTK
0.2222
p.T2126S
TCGA-AP-A059
UCEC
TCGA
DPYSQPP
CBL_PTK
0.25
p.T2126S
DO41361
UCEC
ICGC
DPYSQPP
CBL_PTK
0.25
p.I2122M
TCGA-IB-7651
PAAD
TCGA
DPYSQPP
CBL_PTK
0.1389
p.I2122M
DO46657
PAAD
ICGC
DPYSQPP
CBL_PTK
0.1389
p.D2129E
DO228974
LICA
ICGC
DPYSQPP
CBL_PTK
0.6758
p.Y2145C
DO27779
MALY
ICGC
DPYSQPP
CBL_PTK
0.0556
p.R2139L
ACH-001029
Bone Cancer
CCLE
DPYSQPP
CBL_PTK
0.2222
p.R2139L
ACH-001034
Bone Cancer
CCLE
DPYSQPP
CBL_PTK
0.2222
Drug responses associated with KMT2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPYSQPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEZ4
Histone-lysine N-methyltransferase 2C
CBL_PTK
2129:2135
DPYSQPP
CBL
0.9833
More...
