DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PQTPRPS
Uniprot ID:
Q8NEZ4
Source protein:
Histone-lysine N-methyltransferase 2C
Source gene:
KMT2C
Class:
DEG_SCF_FBW7_1
Location:
2178:2184
E3 ligase:
FBXW7
DEGRON score:
0.9953
ASA_SCORE:
97.4571
COIL:
0.9654
CONS_SCORE:
0.3808
DSS_SCORE:
0.8319
HELIX:
0.0179
FCONS_SCORE:
1.1676
RIG_SCORE:
0.5969
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T2170I
TCGA-DU-6392
LGG
TCGA
PQTPRPS
DEG_SCF_FBW7_1
0.1111
p.T2170I
DO22237
LGG
ICGC
PQTPRPS
DEG_SCF_FBW7_1
0.1111
p.S2184C
TCGA-ET-A3DU
THCA
TCGA
PQTPRPS
DEG_SCF_FBW7_1
0.7541
p.S2184C
DO39464
THCA
ICGC
PQTPRPS
DEG_SCF_FBW7_1
0.7541
p.P2193H
DO229038
LICA
ICGC
PQTPRPS
DEG_SCF_FBW7_1
0.0833
Drug responses associated with KMT2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQTPRPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEZ4
Histone-lysine N-methyltransferase 2C
DEG_SCF_FBW7_1
2178:2184
PQTPRPS
FBXW7
0.9953
More...