DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SCF_FBW7_1

Location: 2178:2184

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 97.4571

COIL: 0.9654

CONS_SCORE: 0.3808

DSS_SCORE: 0.8319

HELIX: 0.0179

FCONS_SCORE: 1.1676

RIG_SCORE: 0.5969

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2184C	TCGA-ET-A3DU	THCA	TCGA	PQTPRPS	DEG_SCF_FBW7_1	0.7541
p.S2184C	DO39464	THCA	ICGC	PQTPRPS	DEG_SCF_FBW7_1	0.7541
p.T2170I	TCGA-DU-6392	LGG	TCGA	PQTPRPS	DEG_SCF_FBW7_1	0.1111
p.T2170I	DO22237	LGG	ICGC	PQTPRPS	DEG_SCF_FBW7_1	0.1111
p.P2193H	DO229038	LICA	ICGC	PQTPRPS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	2178:2184	PQTPRPS	FBXW7	0.9953	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons