DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_COP1_1

Location: 4114:4124

E3 ligase: COP1

DEGRON score: 0.6687

ASA_SCORE: 73.8909

COIL: 0.7262

CONS_SCORE: 0.376

DSS_SCORE: 0.3396

HELIX: 0.0292

FCONS_SCORE: 0.9748

RIG_SCORE: 0.6873

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F4121S	DO223282	UCEC	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.7982
p.E4114K	TCGA-C5-A7CH	CESC	TCGA	EVSSAPDVPSM	DEG_COP1_1	0.7022
p.E4114K	TCGA-GU-AATP	BLCA	TCGA	EVSSAPDVPSM	DEG_COP1_1	0.7022
p.A4122V	DO233652	GACA	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.6936
p.P4116S	DO227549	COCA	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.6752
p.P4119L	TCGA-DD-A73G	LIHC	TCGA	EVSSAPDVPSM	DEG_COP1_1	0.6471
p.V4115G	SW1088	central_nervous_system	COSMIC	EVSSAPDVPSM	DEG_COP1_1	0.6421
p.V4115F	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	EVSSAPDVPSM	DEG_COP1_1	0.5957
p.V4115F	ACH-000666	Lung Cancer	CCLE	EVSSAPDVPSM	DEG_COP1_1	0.5957
p.V4115F	NCI-H1355	lung	COSMIC	EVSSAPDVPSM	DEG_COP1_1	0.5957
p.P4127S	DO52048	HNSC	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.25
p.G4131V	DO48451	BLCA	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.1389
p.S4107L	DO37931	SKCM	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.1389
p.L4105V	TCGA-D1-A1O5	UCEC	TCGA	EVSSAPDVPSM	DEG_COP1_1	0.0833
p.R4133T	DO222423	MELA	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.0833
p.R4133T	DO37425	SKCM	ICGC	EVSSAPDVPSM	DEG_COP1_1	0.0833

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_COP1_1	4114:4124	EVSSAPDVPSM	COP1	0.6687	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons