DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EVSSAPDVPSM
Uniprot ID:
Q8NEZ4
Source protein:
Histone-lysine N-methyltransferase 2C
Source gene:
KMT2C
Class:
DEG_COP1_1
Location:
4114:4124
E3 ligase:
COP1
DEGRON score:
0.6687
ASA_SCORE:
73.8909
COIL:
0.7262
CONS_SCORE:
0.376
DSS_SCORE:
0.3396
HELIX:
0.0292
FCONS_SCORE:
0.9748
RIG_SCORE:
0.6873
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E4114K
TCGA-C5-A7CH
CESC
TCGA
EVSSAPDVPSM
DEG_COP1_1
0.7022
p.E4114K
TCGA-GU-AATP
BLCA
TCGA
EVSSAPDVPSM
DEG_COP1_1
0.7022
p.L4105V
TCGA-D1-A1O5
UCEC
TCGA
EVSSAPDVPSM
DEG_COP1_1
0.0833
p.P4119L
TCGA-DD-A73G
LIHC
TCGA
EVSSAPDVPSM
DEG_COP1_1
0.6471
p.G4131V
DO48451
BLCA
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.1389
p.P4116S
DO227549
COCA
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.6752
p.A4122V
DO233652
GACA
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.6936
p.P4127S
DO52048
HNSC
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.25
p.R4133T
DO222423
MELA
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.0833
p.R4133T
DO37425
SKCM
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.0833
p.S4107L
DO37931
SKCM
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.1389
p.F4121S
DO223282
UCEC
ICGC
EVSSAPDVPSM
DEG_COP1_1
0.7982
p.V4115F
SIDM00645
Non-Small Cell Lung Carcinoma
GDSC
EVSSAPDVPSM
DEG_COP1_1
0.5957
p.V4115F
ACH-000666
Lung Cancer
CCLE
EVSSAPDVPSM
DEG_COP1_1
0.5957
p.V4115F
NCI-H1355
lung
COSMIC
EVSSAPDVPSM
DEG_COP1_1
0.5957
p.V4115G
SW1088
central_nervous_system
COSMIC
EVSSAPDVPSM
DEG_COP1_1
0.6421
Drug responses associated with KMT2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EVSSAPDVPSM
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NEZ4
Histone-lysine N-methyltransferase 2C
DEG_COP1_1
4114:4124
EVSSAPDVPSM
COP1
0.6687
More...