DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: LIG_APCC_ABBA_1

Location: 700:705

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9818

ASA_SCORE: 99.0667

COIL: 0.8277

CONS_SCORE: 0.2626

DSS_SCORE: 0.4454

HELIX: 0.1618

FCONS_SCORE: 1.0665

RIG_SCORE: 0.7142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L694F	TCGA-DK-A3IT	BLCA	TCGA	VSPHEE	LIG_APCC_ABBA_1	0.1667
p.L694F	DO779	BLCA	ICGC	VSPHEE	LIG_APCC_ABBA_1	0.1667
p.T698I	TCGA-FW-A3R5	SKCM	TCGA	VSPHEE	LIG_APCC_ABBA_1	0.2778
p.T698I	DO37406	SKCM	ICGC	VSPHEE	LIG_APCC_ABBA_1	0.2778
p.S691C	DO224598	BRCA	ICGC	VSPHEE	LIG_APCC_ABBA_1	0.0833
p.S691C	DO1010	BRCA	ICGC	VSPHEE	LIG_APCC_ABBA_1	0.0833
p.H703L	DO228827	LICA	ICGC	VSPHEE	LIG_APCC_ABBA_1	0.7313
p.P695Q	DO228976	LICA	ICGC	VSPHEE	LIG_APCC_ABBA_1	0.1944
p.E705V	SIDM00293	Small Cell Lung Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	0.7693
p.E705V	ACH-002052	Lung Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	0.7693
p.E705V	LU-139	lung	COSMIC	VSPHEE	LIG_APCC_ABBA_1	0.7693
p.T693A	SIDM00487	Colorectal Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	0.1389
p.T693A	ACH-000963	Colon/Colorectal Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	0.1389
p.T693A	CCK-81	large_intestine	COSMIC	VSPHEE	LIG_APCC_ABBA_1	0.1389
p.E712G	SIDM00217	Colorectal Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	0.1389
p.E712G	ACH-000999	Colon/Colorectal Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	0.1389
p.E712G	SNU-1040	large_intestine	COSMIC	VSPHEE	LIG_APCC_ABBA_1	0.1389
p.H703Y	SIDM01664	Prostate Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	0.6118
p.H703Y	ACH-000952	Prostate Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	LIG_APCC_ABBA_1	700:705	VSPHEE	APC,CDC20,FZR1	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons