DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_COP1_1

Location: 570:579

E3 ligase: COP1

DEGRON score: 0.7015

ASA_SCORE: 85.67

COIL: 0.8969

CONS_SCORE: 0.2751

DSS_SCORE: 0.6954

HELIX: 0.0428

FCONS_SCORE: 1.1181

RIG_SCORE: 0.659

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P573H	TCGA-AP-A1DV	UCEC	TCGA	ESTPGIVPDA	DEG_COP1_1	0.6583
p.P573H	DO43186	UCEC	ICGC	ESTPGIVPDA	DEG_COP1_1	0.6583
p.G568S	DO222492	COCA	ICGC	ESTPGIVPDA	DEG_COP1_1	0.2778
p.V582I	TCGA-CA-6717	COAD	TCGA	ESTPGIVPDA	DEG_COP1_1	0.25
p.V582I	DO8264	COAD	ICGC	ESTPGIVPDA	DEG_COP1_1	0.25
p.K589N	TCGA-JX-A3Q0	CESC	TCGA	ESTPGIVPDA	DEG_COP1_1	0.1667
p.K589N	DO51607	CESC	ICGC	ESTPGIVPDA	DEG_COP1_1	0.1667
p.Q588H	DO229058	LICA	ICGC	ESTPGIVPDA	DEG_COP1_1	0.0833
p.A561T	SIDM00282	Colorectal Carcinoma	GDSC	ESTPGIVPDA	DEG_COP1_1	0.0833
p.A561T	ACH-000998	Colon/Colorectal Cancer	CCLE	ESTPGIVPDA	DEG_COP1_1	0.0833
p.A561T	CW-2	large_intestine	COSMIC	ESTPGIVPDA	DEG_COP1_1	0.0833
p.Q560L	TCGA-43-8115	LUSC	TCGA	ESTPGIVPDA	DEG_COP1_1	0.0556
p.Q560L	DO26440	LUSC	ICGC	ESTPGIVPDA	DEG_COP1_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_COP1_1	570:579	ESTPGIVPDA	COP1	0.7015	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons