DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SCF_FBW7_2

Location: 741:746

E3 ligase: FBXW7

DEGRON score: 0.8935

ASA_SCORE: 87.1

COIL: 0.8262

CONS_SCORE: 0.2529

DSS_SCORE: 0.5026

HELIX: 0.1155

FCONS_SCORE: 0.9781

RIG_SCORE: 0.7464

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P743L	SIDM00607	Glioblastoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.7582
p.P743L	SIDM00566	Oral Cavity Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.7582
p.P743L	SIDM00241	Breast Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.7582
p.P743L	SIDM01578	Bladder Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.7582
p.M741T	SIDM00437	Acute Myeloid Leukemia	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.7423
p.M741T	SIDM00290	Gastric Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.7423
p.M741T	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	MTPTIE	DEG_SCF_FBW7_2	0.7423
p.M741T	HGC-27	stomach	COSMIC	MTPTIE	DEG_SCF_FBW7_2	0.7423
p.E746Q	DO230535	LUSC	ICGC	MTPTIE	DEG_SCF_FBW7_2	0.6744
p.T744A	DO230538	LUSC	ICGC	MTPTIE	DEG_SCF_FBW7_2	0.6028
p.T744A	SIDM01608	Endometrial Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.6028
p.T744A	ACH-000990	Endometrial/Uterine Cancer	CCLE	MTPTIE	DEG_SCF_FBW7_2	0.6028
p.E740K	TCGA-IR-A3LK	CESC	TCGA	MTPTIE	DEG_SCF_FBW7_2	0.3056
p.E740K	TCGA-WS-AB45	COAD	TCGA	MTPTIE	DEG_SCF_FBW7_2	0.3056
p.E740K	DO44299	CESC	ICGC	MTPTIE	DEG_SCF_FBW7_2	0.3056
p.E740K	DO51734	COAD	ICGC	MTPTIE	DEG_SCF_FBW7_2	0.3056
p.C748F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.2778
p.M737V	SIDM01638	Non-Cancerous	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.2222
p.M737V	SIDM00172	Head and Neck Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.2222
p.L732H	SIDM01473	Plasma Cell Myeloma	GDSC	MTPTIE	DEG_SCF_FBW7_2	0.0833
p.G756R	TCGA-74-6577	GBM	TCGA	MTPTIE	DEG_SCF_FBW7_2	0.0556
p.G756R	DO13941	GBM	ICGC	MTPTIE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_2	741:746	MTPTIE	FBXW7	0.8935	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons