DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: CBL_PTK

Location: 2088:2098

E3 ligase: CBL

DEGRON score: 0.9258

ASA_SCORE: 97.8727

COIL: 0.9623

CONS_SCORE: 0.386

DSS_SCORE: 0.7605

HELIX: 0.0253

FCONS_SCORE: 1.052

RIG_SCORE: 0.5677

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2101A	TCGA-23-1110	OV	TCGA	NQSNDPYSQPP	CBL_PTK	0.25
p.P2101A	DO29398	OV	ICGC	NQSNDPYSQPP	CBL_PTK	0.25
p.I2082V	TCGA-46-3768	LUSC	TCGA	NQSNDPYSQPP	CBL_PTK	0.1667
p.I2082V	DO26466	LUSC	ICGC	NQSNDPYSQPP	CBL_PTK	0.1667
p.D2092Y	TCGA-97-7547	LUAD	TCGA	NQSNDPYSQPP	CBL_PTK	0.6214
p.D2092Y	DO23594	LUAD	ICGC	NQSNDPYSQPP	CBL_PTK	0.6214
p.S2108Y	TCGA-AA-3977	COAD	TCGA	NQSNDPYSQPP	CBL_PTK	0.0556
p.S2108Y	DO8730	COAD	ICGC	NQSNDPYSQPP	CBL_PTK	0.0556
p.N2088S	TCGA-CN-A498	HNSC	TCGA	NQSNDPYSQPP	CBL_PTK	0.7069
p.N2088S	DO52038	HNSC	ICGC	NQSNDPYSQPP	CBL_PTK	0.7069
p.S2095N	TCGA-D3-A2JH	SKCM	TCGA	NQSNDPYSQPP	CBL_PTK	0.7069
p.S2095N	DO47263	SKCM	ICGC	NQSNDPYSQPP	CBL_PTK	0.7069
p.L2099P	TCGA-EO-A22R	UCEC	TCGA	NQSNDPYSQPP	CBL_PTK	0.3056
p.L2099P	DO42713	UCEC	ICGC	NQSNDPYSQPP	CBL_PTK	0.3056
p.D2083Y	TCGA-FS-A1Z0	SKCM	TCGA	NQSNDPYSQPP	CBL_PTK	0.1944
p.D2083Y	DO37431	SKCM	ICGC	NQSNDPYSQPP	CBL_PTK	0.1944
p.P2093T	TCGA-IB-7651	PAAD	TCGA	NQSNDPYSQPP	CBL_PTK	0.5919
p.P2093T	DO46657	PAAD	ICGC	NQSNDPYSQPP	CBL_PTK	0.5919
p.T2078A	TCGA-IG-A3QL	ESCA	TCGA	NQSNDPYSQPP	CBL_PTK	0.0556
p.V2105M	TCGA-VQ-A8PO	STAD	TCGA	NQSNDPYSQPP	CBL_PTK	0.1389
p.V2105M	DO51773	STAD	ICGC	NQSNDPYSQPP	CBL_PTK	0.1389
p.A2104V	DO222548	COCA	ICGC	NQSNDPYSQPP	CBL_PTK	0.1667
p.N2088I	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	0.728
p.Y2094F	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	0.7528
p.S2095G	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	0.6993
p.N2106I	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	0.1111
p.L2099F	DO222363	MELA	ICGC	NQSNDPYSQPP	CBL_PTK	0.3056
p.T2100S	DO229584	PRAD	ICGC	NQSNDPYSQPP	CBL_PTK	0.2778
p.D2092V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	NQSNDPYSQPP	CBL_PTK	0.6674
p.D2092V	SIDM00863	Burkitt's Lymphoma	GDSC	NQSNDPYSQPP	CBL_PTK	0.6674
p.D2092V	SIDM00808	Burkitt's Lymphoma	GDSC	NQSNDPYSQPP	CBL_PTK	0.6674
p.D2092V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	NQSNDPYSQPP	CBL_PTK	0.6674
p.D2092V	SIDM01254	Burkitt's Lymphoma	GDSC	NQSNDPYSQPP	CBL_PTK	0.6674
p.P2093S	SIDM01175	Other Sarcomas	GDSC	NQSNDPYSQPP	CBL_PTK	0.5641
p.P2093S	ACH-002309	Sarcoma	CCLE	NQSNDPYSQPP	CBL_PTK	0.5641
p.P2093S	SW684	soft_tissue	COSMIC	NQSNDPYSQPP	CBL_PTK	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NQSNDPYSQPP

Degron related mutations and impact score

Drug responses associated with KMT2C mutations

All proteins holding degron of NQSNDPYSQPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	CBL_PTK	2088:2098	NQSNDPYSQPP	CBL	0.9258	More...